Expression of platelet endothelial cell adhesion molecule-1 between pancreatic microcirculation and peripheral circulation in rats with acute edematous pancreatitis

被引：2

作者：

HongKai Gao

ZongGuang Zhou

YouQin Chen

FangHai Han

Cun Wang the Department of General Surgery and Institute of Digestive Surgery West China Hospital Sichuan University Chengdu China ^{[610041
]}

机构：

来源：

Hepatobiliary&PancreaticDiseasesInternational | 2003年 / 03期

关键词：

acute edematous pancreatitis; peripheral circulation; pancretic microcirculation; polymorphonuclear leukocyte; platelet endothelial cell adhesion molecules-1;

D O I：

暂无

中图分类号：

R576 [胰腺疾病];

学科分类号：

1002 ; 100201 ;

摘要：

<正> OBJECTIVE: To study the ehanges of platelet endothelial cell adhesion molecule-1 (PECAM-1)expression on polymorphonuclear leukocytes (PMNs) in peripheral circulation anti pancreaticmicrocirculation in rats with acute edematous pancreatitis (AEP).METHODS: The model of AEP was established with 50 Wistar rats, and the changes of PECAM-1expression on PMNs from the splenic vein and inferior vena cava were determined by flow cytometry.RESULTS: PECAM-I expression on PMNs showed no significant difference between pancreaticmicrocirculation and peripheral circulation at AEP2h and AEP4h time points. From the AEP4h to theAEP8h time point, PECAM-1 expression in peripheral circulation was up-regulated, but PECAM-1expression in pancreatic microcirculation was down-regulated. PECAM-1 expression had a significantdifference between pancreatic microcirculation and peripheral circulation at the AEP8h time point(P<0.05).CONCLUSION: PECAM-1 expression on PMNs is in a converse way between pancreatic microcirculationand peripheral circulation in AEP.

引用

页码：463 / 466

页数：4

共 4 条

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