IL28B基因多态性与慢性丙型肝炎抗病毒治疗疗效的关系探讨

被引:2
作者
廖祥伟
龚启明
张欣欣
机构
[1] 上海交通大学医学院附属瑞金医院感染科
关键词
丙型肝炎病毒(HCV); 疗效; IL28B; 基因多态性(SNP);
D O I
暂无
中图分类号
R512.63 [];
学科分类号
摘要
慢性丙型肝炎是一个严重危害人类健康的公共卫生问题。联合抗病毒治疗的疗效受到宿主遗传因素的影响,尤其是IL28B基因多态性的影响。本文综述IL28B基因多态性与慢性丙型肝炎抗病毒治疗疗效的关系。
引用
收藏
页码:723 / 726
页数:4
相关论文
共 10 条
[1]   Low-density lipoprotein receptor genotyping enhances the predictive value of IL28B genotype in HIV/hepatitis C virus-coinfected patients [J].
Pineda, Juan A. ;
Caruz, Antonio ;
Di Lello, Federico A. ;
Camacho, Angela ;
Mesa, Pilar ;
Neukam, Karin ;
Rivero-juarez, Antonio ;
Macias, Juan ;
Gomez-Mateos, Jesus ;
Rivero, Antonio .
AIDS, 2011, 25 (11) :1415-1420
[2]   Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C [J].
Tillmann, Hans L. ;
Patel, Keyur ;
Muir, Andrew J. ;
Guy, Cynthia D. ;
Li, Josephine H. ;
Lao, Xiang Qian ;
Thompson, Alexander ;
Clark, Paul J. ;
Gardner, Stephen D. ;
McHutchison, John G. ;
McCarthy, Jeanette J. .
JOURNAL OF HEPATOLOGY, 2011, 55 (06) :1195-1200
[3]  
Realize the advance in HCV treatment, but remain cautious[J] . Tarik Asselah.Journal of Hepatology . 2011 (6)
[4]   IL28B Genotype Is Associated With Differential Expression of Intrahepatic Interferon-Stimulated Genes in Patients With Chronic Hepatitis C [J].
Urban, Thomas J. ;
Thompson, Alexander J. ;
Bradrick, Shelton S. ;
Fellay, Jacques ;
Schuppan, Detlef ;
Cronin, Kenneth D. ;
Hong, Linda ;
McKenzie, Alexander ;
Patel, Keyur ;
Shianna, Kevin V. ;
McHutchison, John G. ;
Goldstein, David B. ;
Afdhal, Nezam .
HEPATOLOGY, 2010, 52 (06) :1888-1896
[5]   Hepatic ISG Expression Is Associated With Genetic Variation in Interleukin 28B and the Outcome of IFN Therapy for Chronic Hepatitis C [J].
Honda, Masao ;
Sakai, Akito ;
Yamashita, Tatsuya ;
Nakamoto, Yasunari ;
Mizukoshi, Eishiro ;
Sakai, Yoshio ;
Yamashita, Taro ;
Nakamura, Mikiko ;
Shirasaki, Takayoshi ;
Horimoto, Katsuhisa ;
Tanaka, Yasuhito ;
Tokunaga, Katsushi ;
Mizokami, Masashi ;
Kaneko, Shuichi .
GASTROENTEROLOGY, 2010, 139 (02) :499-509
[6]   Interleukin-28B Polymorphism Improves Viral Kinetics and Is the Strongest Pretreatment Predictor of Sustained Virologic Response in Genotype 1 Hepatitis C Virus [J].
Thompson, Alexander J. ;
Muir, Andrew J. ;
Sulkowski, Mark S. ;
Ge, Dongliang ;
Fellay, Jacques ;
Shianna, Kevin V. ;
Urban, Thomas ;
Afdhal, Nezam H. ;
Jacobson, Ira M. ;
Esteban, Rafael ;
Poordad, Fred ;
Lawitz, Eric J. ;
McCone, Jonathan ;
Shiffman, Mitchell L. ;
Galler, Greg W. ;
Lee, William M. ;
Reindollar, Robert ;
King, John W. ;
Kwo, Paul Y. ;
Ghalib, Reem H. ;
Freilich, Bradley ;
Nyberg, Lisa M. ;
Zeuzem, Stefan ;
Poynard, Thierry ;
Vock, David M. ;
Pieper, Karen S. ;
Patel, Keyur ;
Tillmann, Hans L. ;
Noviello, Stephanie ;
Koury, Kenneth ;
Pedicone, Lisa D. ;
Brass, Clifford A. ;
Albrecht, Janice K. ;
Goldstein, David B. ;
McHutchison, John G. .
GASTROENTEROLOGY, 2010, 139 (01) :120-+
[7]   An IL28B Polymorphism Determines Treatment Response of Hepatitis C Virus Genotype 2 or 3 Patients Who Do Not Achieve a Rapid Virologic Response [J].
Mangia, Alessandra ;
Thompson, Alexander J. ;
Santoro, Rosanna ;
Piazzolla, Valeria ;
Tillmann, Hans L. ;
Patel, Keyur ;
Shianna, Kevin V. ;
Mottola, Leonardo ;
Petruzzellis, Daniela ;
Bacca, Donato ;
Carretta, Vito ;
Minerva, Nicola ;
Goldstein, David B. ;
Mchutchison, John G. .
GASTROENTEROLOGY, 2010, 139 (03) :821-U164
[8]  
Genetic Variation in IL28B Is Associated With Chronic Hepatitis C and Treatment Failure: A Genome-Wide Association Study[J] . Gastroenterology . 2010 (4)
[9]  
1179 INTERFERON LAMBDA GENOTYPE AND LOW SERUM LDL CHOLESTEROL LEVELS IN PATIENTS WITH CHRONIC HEPATITIS C INFECTION[J] . J.H. Li,X.Q. Lao,H. Tillmann,J. Rowell,K. Patel,A.J. Thompson,S. Suchindran,A.J. Muir,J.R. Guyton,S.D. Gardner,J.G. McHutchison,J. McCarthy.Journal of Hepatology . 2010
[10]   Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in HIV/hepatitis C virus-coinfected patients [J].
Rallon, Norma I. ;
Naggie, Susanna ;
Benito, Jose M. ;
Medrano, Jose ;
Restrepo, Clara ;
Goldstein, David ;
Shianna, Kevin V. ;
Vispo, Eugenia ;
Thompson, Alex ;
McHutchison, John ;
Soriano, Vincent .
AIDS, 2010, 24 (08) :F23-F29