治疗方案对2型糖尿病患者抑郁情绪影响的调查研究

被引：12

作者：

吴冰 ^{[1
]}

陈璇 ^{[1
]}

杨莉 ^{[2
]}

周方圆 ^{[1
]}

陈娜 ^{[1
]}

吴静 ^{[1
]}

机构：

[1] 南京中医药大学护理学院

[2] 江苏省中医院内分泌科

来源：

中华内分泌代谢杂志 | 2015年 / 31卷 / 04期

关键词：

糖尿病, 2型; 抑郁; 胰岛素; 口服药;

D O I：

暂无

中图分类号：

R587.2 [糖尿病性昏迷及其他并发症]; R749 [精神病学];

学科分类号：

100201 [内科学]; 100204 [神经病学];

摘要：

探讨胰岛素与口服降糖药物治疗对2型糖尿病患者抑郁情绪的影响。随机抽取江苏省中医院内分泌科门诊及住院的2型糖尿病患者283例, 使用自行设计的问卷和Zung抑郁自评量表(SDS)开展横断面调查。利用t检验或χ2比较不同治疗方案组患者的基本情况。应用logistic回归分析治疗方案与抑郁情绪的关系。结果显示43.1%的2型糖尿病患者存在不同程度的抑郁症状。与口服药物组相比, 胰岛素组存在抑郁的比例更高(胰岛素组53.5%, 口服药物组30.5%;P<0.01), SDS得分更高[胰岛素组(51.7±12.4)分, 口服药物组(44.8±10.6)分;P<0.01]。通过校正年龄、性别、体重指数、糖尿病病程、并发症及HbA1C等多因素后, 胰岛素组抑郁发生率仍高于口服药物组(OR=4.218, 95%CI 1.764～13.285,P=0.004)。胰岛素治疗是2型糖尿病患者抑郁发生的独立危险因素, 有必要对此类患者加强心理支持。

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