原发性胆汁性肝硬化药物治疗进展

被引:13
作者
李萍英 [1 ]
陆伦根 [2 ]
机构
[1] 青海省人民医院消化科
[2] 上海交通大学附属第一人民医院消化科
关键词
原发性胆汁性肝硬化; 药物治疗; 进展;
D O I
暂无
中图分类号
R575.2 [肝硬变];
学科分类号
100201 [内科学];
摘要
治疗原发性胆汁性肝硬化(PBC)的药物主要包括加速胆汁排泄、免疫调节、抗纤维化以及对症治疗等。熊去氧胆酸是目前唯一被批准治疗PBC的药物,对大多数患者有较好的疗效,但仍有部分患者不应答。另外,贝特类、6-乙基鹅去氧胆酸、布地奈德等用于PBC的治疗也显示有很好的前景,这些研究结果为PBC的治疗提供了新选择。
引用
收藏
页码:441 / 444
页数:4
相关论文
共 22 条
[1]
Old and Novel Therapies for Primary Biliary Cirrhosis[J] Albert Parés Semin Liver Dis 2014,
[2]
Obeticholic acid and budesonide for the treatment of primary biliary cirrhosis[J] Marina G Silveira;Keith D Lindor Expert Opinion on Pharmacotherapy 2014,
[3]
Randomized controlled trial assessing the effect of simvastatin in primary biliary cirrhosis[J] William J. Cash;Stephen O'Neill;Mark E. O'Donnell;David R. McCance;Ian S. Young;Jane McEneny;Neil I. McDougall;Michael E. Callender Liver Int 2013,
[4]
Natural history and management of primary biliary cirrhosis[J] Teru Kumagi;Nadya Al-Harthy Hepatic Medicine: Evidence and Research 2012,
[5]
Ursodeoxycholic acid and bile-acid mimetics as therapeutic agents for cholestatic liver diseases: An overview of their mechanisms of action[J] Raoul Poupon Clinics and Research in Hepatology and Gastroenterology 2012,
[6]
Role of RANK Ligand and Denosumab; a Targeted RANK Ligand Inhibitor; in Bone Health and Osteoporosis: A Review of Preclinical and Clinical Data[J] David W. Dempster;Cheryl L. Lambing;Paul J. Kostenuik;Andreas Grauer Clinical Therapeutics 2012,
[7]
Colchicine or Methotrexate; With Ursodiol; Are Effective After 20 Years in a Subset of Patients With Primary Biliary Cirrhosis[J] John Leung;Peter A. Bonis;Marshall M. Kaplan Clinical Gastroenterology and Hepatology 2011,
[8]
Primary biliary cirrhosis[J] Carlo Selmi;Christopher L Bowlus;M Eric Gershwin;Ross L Coppel The Lancet 2011,
[9]
Pilot study: fenofibrate for patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid[J] C.Levy;J. A.Peter;D. R.Nelson;J.Keach;J.Petz;R.Cabrera;V.Clark;R. J.Firpi;G.Morelli;C.Soldevila‐Pico;K.Lindor Alimentary Pharmacology & Therapeutics 2010,
[10]
Triple therapy with ursodeoxycholic acid; budesonide and mycophenolate mofetil in patients with features of severe primary biliary cirrhosis not responding to ursodeoxycholic acid alone[J] N. Rabahi;Y. Chrétien;F. Gaouar;D. Wendum;L. Serfaty;O. Chazouillères;C. Corpechot;R. Poupon Gastroenterologie Clinique et Biologique 2010,