人肺癌组织中富含酪氨酸61和结缔组织生长因子的表达

被引：2

作者：

崔玲玲 ^{[1
]}

孙锦峰 ^{[1
]}

王旗 ^{[1
]}

李文杰 ^{[1
]}

陈萍萍 ^{[1
]}

赵松 ^{[2
]}

赵高峰 ^{[2
]}

冯丽云 ^{[1
]}

谢东 ^{[1
]}

机构：

[1] 郑州大学公共卫生学院营养与食品卫生学教研室

[2] 郑州大学第一附属医院胸外科

来源：

郑州大学学报(医学版) | 2007年 / 03期

关键词：

富含酪氨酸61; 结缔组织生长因子; 肺癌;

D O I：

10.13705/j.issn.1671-6825.2007.03.024

中图分类号：

R734.2 [肺肿瘤];

学科分类号：

摘要：

目的研究人肺癌组织中富含酪氨酸61(CYR61)和结缔组织生长因子(CTGF)的基因表达及其与临床参数的关系。方法采用实时定量PCR及免疫组织化学技术对60例肺癌患者的肺癌组织和癌旁正常肺组织CYR61和CTGF基因mRNA表达水平和蛋白表达进行测定,并分析二者的表达与临床参数的关系。结果肺癌组织中CYR61和CTGFmRNA表达水平和蛋白阳性表达率均低于癌旁正常组织(P均<0.05)。肺癌组织中CYR61和CTGFmRNA的表达水平与患者的病理类型、病理分级、淋巴结转移、吸烟及家族史等临床参数有关(P<0.05);肺癌组织中CYR61和CTGFmRNA表达水平呈正相关(r=0.604;P=0.000)。多元回归分析病理类型和年龄对CYR61表达有重要影响,肿瘤的位置、CYR61表达和性别对肺癌组织中的CTGF表达有重要影响。结论CYR61和CTGF单种基因或两者相互作用对肺癌的发展起重要作用,其表达的蛋白产物可作为临床干预治疗的重要靶蛋白。

引用

页码：453 / 457

页数：5

共 11 条

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