抗血管生成药物筛选和研究的体内外模型

被引：5

作者：

袁胜涛

萧东

丁健

机构：

[1] 中国科学院上海药物研究所!上海,中国科学院上海药物研究所!上海,中国科学院上海药物研究所!上海

来源：

国外医学药学分册. | 2000年 / 04期

关键词：

抗血管生成; 模型; 治疗药物; 筛选;

D O I：

10.13220/j.cnki.jipr.2000.04.004

中图分类号：

R965 [实验药理学];

学科分类号：

100602 ; 100706 ;

摘要：

抗血管生成治疗是当今国际上抗肿瘤研究的热点之一。研究抗血管生成药物 ,必须建立有效实用的实验模型和评价标准 ,近年来在这方面有较多新的进展。本文介绍分子、细胞、器官组织和整体水平上目前常用以及新创建的抗血管生成药物筛选和研究的体内外模型 ,并分析了这些模型的特点。分子细胞水平等体外模型的优点是实验容易控制 ,操作较简单 ,实验费用较低 ,样品所需量较少。体内模型的优点是实验条件比较接近今后药物使用的环境。筛选的程序一般为先经体外筛选 ,再经器官组织水平的筛选和研究确证 ,然后应用肿瘤模型进行最终和全面的评价

引用

页码：204 / 208

页数：5

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