肠道菌群紊乱与2型糖尿病相关性探究

被引：19

作者：

朱英倩 ^{[1
]}

雷涛 ^{[2
]}

机构：

[1] 同济大学附属同济医院内分泌科

[2] 上海市中医药大学附属普陀医院内分泌科

来源：

医学综述 | 2017年 / 23卷 / 19期

关键词：

肠道菌群紊乱; 2型糖尿病; 菌群调节;

D O I：

暂无

中图分类号：

R587.1 [糖尿病];

学科分类号：

100201 [内科学];

摘要：

2型糖尿病是一种发病率逐年升高的代谢性疾病,其高发病率和致残率已经严重威胁人类健康,肠道菌群与2型糖尿病的发生和发展关系密切。肠道菌群紊乱可引起脂多糖含量异常、机体慢性炎症,并通过改变短链脂肪酸和胆汁酸代谢导致2型糖尿病的发生和发展。调节肠道菌群、恢复菌群稳态有望成为治疗2型糖尿病的新方法。新型肠道微生态治疗手段包括粪菌移植、减重手术,而盐酸小檗碱、益生元、益生菌、抗生素也因发现可以调节肠道菌群而应用于糖尿病的治疗。这些研究为进一步明确糖尿病的发病机制和诊疗提供新的思路。

引用

页码：3873 / 3877

页数：5

共 24 条

[1]

Effect of antibiotics on gut microbiota, glucose metabolism and body weight regulation: a review of the literature [J].

Mikkelsen, K. H. ;

Allin, K. H. ;

Knop, F. K. .

DIABETES OBESITY & METABOLISM, 2016, 18 (05) :444-453

[2]

Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies [J].

Pirillo, Angela ;

Catapano, Alberico Luigi .

ATHEROSCLEROSIS, 2015, 243 (02) :449-461

[3]

Artesunate alleviates hepatic fibrosis induced by multiple pathogenic factors and inflammation through the inhibition of LPS/TLR4/NF-κB signaling pathway in rats.[J].Lina Lai;Yunxia Chen;Xiaoxia Tian;Xujiong Li;Xiaojing Zhang;Jingwen Lei;Yanghui Bi;Buwu Fang;Xiaoliang Song.European Journal of Pharmacology.2015,

[4]

Targeting gut microbiota as a possible therapy for diabetes [J].

He, Canxia ;

Shan, Yujuan ;

Song, Wei .

NUTRITION RESEARCH, 2015, 35 (05) :361-367

[5]

Bariatric surgery for obesity and metabolic conditions in adults.[J]..BMJ: British Medical Journal.2014,

[6]

Metabolic surgery: Action via hormonal milieu changes, changes in bile acids or gut microbiota? A summary of the literature [J].

Sweeney, Timothy E. ;

Morton, John M. .

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2014, 28 (04) :727-740

[7]

The Role of Short-Chain Fatty Acids in Health and Disease.[J].Jian Tan;Craig McKenzie;Maria Potamitis;Alison N. Thorburn;Charles R. Mackay;Laurence Macia.Advances in Immunology.2014,

[8]

Antioxidant and Anti-Inflammatory Activities of Berberine in the Treatment of Diabetes Mellitus.[J].Zheng Li;Ya-Na Geng;Jian-Dong Jiang;Wei-Jia Kong;Yao Tong.Evidence-Based Complementary and Alternative Medicine.2014,

[9]

Pathobiology and Potential Therapeutic Value of Intestinal Short-Chain Fatty Acids in Gut Inflammation and Obesity [J].

Soldavini, Jessica ;

Kaunitz, Jonathan D. .

DIGESTIVE DISEASES AND SCIENCES, 2013, 58 (10) :2756-2766

[10]

Diabetes, obesity and gut microbiota [J].

Everard, Amandine ;

Cani, Patrice D. .

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2013, 27 (01) :73-83

← 1 2 3 →