miRNA在肾脏缺血再灌注损伤中的作用研究进展

被引：4

作者：

潘旭鸣 ^{[1
]}

陈丹垒 ^{[1
]}

马红珍 ^{[2
]}

机构：

[1] 浙江中医药大学第一临床医学院

[2] 浙江中医药大学附属第一医院肾病科

来源：

浙江医学 | 2019年 / 41卷 / 10期

关键词：

肾脏; 缺血再灌注损伤; 微小RNA; 氧化应激; 自噬; 低氧诱导因子;

D O I：

暂无

中图分类号：

R692 [肾疾病];

学科分类号：

摘要：

肾脏缺血再灌注损伤(IRI)是导致急性肾损伤(AKI)的主要原因之一。肾脏IRI涉及炎症反应、氧化应激反应、细胞凋亡与自噬等过程。miRNA是内源性的、短链非编码RNA,可通过抑制靶m RNA的转录后活性影响转录后翻译过程。miRNA介导的基因调控是调节细胞周期、增殖、生长和凋亡等基本细胞过程的重要调节机制,进而对病理生理结果产生重要影响。研究显示miRNA在多种肾脏疾病发病过程中起关键作用,如IRI、AKI和肾癌。多种miRNA表现出差异性表达,可能通过调节炎症、氧化应激、细胞凋亡和自噬来减轻损伤反应,部分miRNA甚至表现出良好的诊断IRI致AKI的效能。本文就miRNA在肾脏IRI中的作用研究进展作一综述。

引用

页码：1091 / 1095

页数：5

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