酒精性肝炎的临床治疗研究进展

被引:9
作者
黄碧燕 [1 ]
肖桂珍 [1 ]
朱鹏 [2 ]
机构
[1] 解放军第四二一医院营养科
[2] 解放军部队医院内科
关键词
酒精性肝炎; 酒精性肝病; 糖皮质激素; 肝移植;
D O I
10.16680/j.1671-3826.2015.11.32
中图分类号
R575.1 [肝炎];
学科分类号
100201 [内科学];
摘要
<正>酒精性肝病(alcoholic liver disease,ALD)是由于长期大量饮酒所致的肝脏疾病,初期表现为肝组织中的脂肪大量堆积,后期可进展为酒精性肝炎(alcoholic hepatitis,AH)、肝硬化甚至肝细胞癌。AH在ALD中的发病率约为10%35%,AH患者30 d的死亡率约为15%,1年死亡率可达39%,而对于重度AH而言,30 d及1年的死亡率更高(分别为30%及60%),可造成严重的社会与经济负担[1]。除外乙醇导致的肝组织损害,AH患者肝病
引用
收藏
页码:870 / 873
页数:4
相关论文
共 24 条
[1]
Management of acute pancreatitis [J].
Goldenberg, David E. ;
Gordon, Stuart R. ;
Gardner, Timothy B. .
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 2014, 8 (06) :687-694
[2]
Prognosis and treatment of patients with acute alcoholic hepatitis [J].
Papastergiou, Vassilios ;
Burroughs, Andrew K. ;
Tsochatzis, Emmanuel A. .
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 2014, 8 (05) :471-486
[3]
Nine scoring models for short-term mortality in alcoholic hepatitis: cross-validation in a biopsy-proven cohort [J].
Papastergiou, V. ;
Tsochatzis, E. A. ;
Pieri, G. ;
Thalassinos, E. ;
Dhar, A. ;
Bruno, S. ;
Karatapanis, S. ;
Luong, T. V. ;
O'Beirne, J. ;
Patch, D. ;
Thorburn, D. ;
Burroughs, A. K. .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2014, 39 (07) :721-732
[4]
Invasive aspergillosis in patients with severe alcoholic hepatitis [J].
Gustot, Thierry ;
Maillart, Evelyne ;
Bocci, Massimo ;
Surin, Rudy ;
Trepo, Eric ;
Degre, Delphine ;
Lucidi, Valerio ;
Taccone, Fabio Silvio ;
Delforge, Marie-Luce ;
Vincent, Jean-Louis ;
Donckier, Vincent ;
Jacobs, Frederique ;
Moreno, Christophe .
JOURNAL OF HEPATOLOGY, 2014, 60 (02) :267-274
[5]
Efficacy of Disulfiram for the Treatment of Alcohol Dependence Assessed with a Multicenter Randomized Controlled Trial [J].
Yoshimura, Atsushi ;
Kimura, Mitsuru ;
Nakayama, Hisakazu ;
Matsui, Toshifumi ;
Okudaira, Fukiko ;
Akazawa, Shigeru ;
Ohkawara, Masao ;
Cho, Tetsuji ;
Kono, Yoshihiro ;
Hashimoto, Koji ;
Kumagai, Masayuki ;
Sahashi, Yukiko ;
Roh, Sungwon ;
Higuchi, Susumu .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2014, 38 (02) :572-578
[6]
A Histologic Scoring System for Prognosis of Patients With Alcoholic Hepatitis [J].
Altamirano, Jose ;
Miquel, Rosa ;
Katoonizadeh, Aezam ;
Abraldes, Juan G. ;
Duarte-Rojo, Andres ;
Louvet, Alexandre ;
Augustin, Salvador ;
Mookerjee, Rajeshwar P. ;
Michelena, Javier ;
Smyrk, Thomas C. ;
Buob, David ;
Leteurtre, Emmanuelle ;
Rincon, Diego ;
Ruiz, Pablo ;
Garcia-Pagan, Juan Carlos ;
Guerrero-Marquez, Carmen ;
Jones, Patricia D. ;
Barritt, A. Sidney ;
Arroyo, Vicente ;
Bruguera, Miquel ;
Banares, Rafael ;
Gines, Pere ;
Caballeria, Juan ;
Roskams, Tania ;
Nevens, Frederik ;
Jalan, Rajiv ;
Mathurin, Philippe ;
Shah, Vijay H. ;
Bataller, Ramon .
GASTROENTEROLOGY, 2014, 146 (05) :1231-+
[7]
The Alcohol Relapse Risk Assessment: a scoring system to predict the risk of relapse to any alcohol use after liver transplant [J].
Rodrigue, James R. ;
Hanto, Douglas W. ;
Curry, Michael P. .
PROGRESS IN TRANSPLANTATION, 2013, 23 (04) :310-318
[8]
Determinants of long-term outcome in severe alcoholic hepatitis [J].
Potts, J. R. ;
Goubet, S. ;
Heneghan, M. A. ;
Verma, S. .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2013, 38 (06) :584-595
[9]
Intravenous acetylcysteine for indications other than acetaminophen overdose [J].
Bass, Stephanie ;
Zook, Nathaniel .
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY, 2013, 70 (17) :1496-1501
[10]
Systematic review: pentoxifylline for the treatment of severe alcoholic hepatitis.[J].R. Parker;M. J. Armstrong;C. Corbett;I. A. Rowe;D. D. Houlihan.Aliment Pharmacol Ther.2013, 9