趋化因子受体CCR7的免疫学功能研究进展

被引：6

作者：

欧阳容兰 ^{[1
]}

张栋梁 ^{[2
]}

李小毅 ^{[1
]}

张勇 ^{[1
]}

黄书润 ^{[1
]}

机构：

[1] 解放军医院烧伤整形外科

[2] 第四军医大学西京医院整形外科研究所

来源：

解放军医药杂志 | 2015年 / 27卷 / 04期

关键词：

受体,CCR7; 趋化因子CCL19; 趋化因子CCL21; 免疫;

D O I：

暂无

中图分类号：

R392.12 [免疫细胞生物学];

学科分类号：

100108 [医学免疫学];

摘要：

<正>免疫系统的一个重要特点是能够对外来病原体产生保护性免疫应答,而对自身及环境中无害的抗原保持免疫耐受。近来研究表明,趋化因子受体CCR7(CC-chemokine receptor 7)通过参与胸腺结构和功能的构建,介导免疫细胞归巢至淋巴器官(如初始及调节性T细胞通过高内皮微静脉归巢至引

引用

页码：108 / 112

页数：5

共 8 条

[1]

Deficient CCR7 signaling promotes T<sub>H</sub>2 polarization and B‐cell activation in vivo.[J].G. L. Moschovakis;Anja Bubke;Oliver Dittrich‐Breiholz;Asolina Braun;Immo Prinz;Elisabeth Kremmer;Reinhold F?rster.Eur. J. Immunol..2011, 1

[2]

Lymph Node T Cell Homeostasis Relies on Steady State Homing of Dendritic Cells [J].

Wendland, Meike ;

Willenzon, Stefanie ;

Kocks, Jessica ;

Davalos-Misslitz, Ana Clara ;

Hammerschmidt, Swantje I. ;

Schumann, Kathrin ;

Kremmer, Elisabeth ;

Sixt, Michael ;

Hoffmeyer, Angelika ;

Pabst, Oliver ;

Foerstert, Reinhold .

IMMUNITY, 2011, 35 (06) :945-957

[3]

CCL21 is sufficient to mediate DC migration, maturation and function in the absence of CCL19 [J].

Britschgi, Mirjam R. ;

Favre, Stephanie ;

Luther, Sanjiv A. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2010, 40 (05) :1266-1271

[4]

Factors and signals that govern the migration of dendritic cells via lymphatics: recent advances.[J].Gwendalyn J. Randolph;Guzman Sanchez-Schmitz;Veronique Angeli.Springer Seminars in Immunopathology.2004, 3

[5]

CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions [J].

Ohl, L ;

Mohaupt, M ;

Czeloth, N ;

Hintzen, G ;

Kiafard, Z ;

Zwirner, J ;

Blankenstein, T ;

Henning, G ;

Forster, R .

IMMUNITY, 2004, 21 (02) :279-288

[6]

Prolongation of allograft survival in CCR7-deficient mice [J].

Beckmann, JH ;

Yan, S ;

Lührs, H ;

Heid, B ;

Skubich, S ;

Förster, R ;

Hoffmann, MW .

TRANSPLANTATION, 2004, 77 (12) :1809-1814

[7]

CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs [J].

Förster, R ;

Schubel, A ;

Breitfeld, D ;

Kremmer, E ;

Renner-Müller, I ;

Wolf, E ;

Lipp, M .

CELL, 1999, 99 (01) :23-33

[8]

Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells..Tim Worbs;Ulrike Bode;Sheng Yan;Matthias W. Hoffmann;Gabriele Hintzen;Günter Bernhardt;Reinhold Frster;Oliver Pab;.J. Exp. Med.2006,

← 1 →