益生菌治疗炎症性肠病的机制研究进展

被引：12

作者：

付一鸣 ^{[1
]}

戴世学 ^{[2
,3
]}

沙卫红 ^{[2
,3
]}

机构：

[1] 南方医科大学第一临床医学院, 广州

[2] 广东省人民医院(广东省医学科学院)消化内科, 广州

[3] 广东省老年医学研究所, 广州

来源：

中华消化杂志 | 2019年 / 39卷 / 03期

基金：

中国博士后科学基金; 广东省自然科学基金;

关键词：

D O I：

暂无

中图分类号：

R574 [肠疾病];

学科分类号：

100201 [内科学];

摘要：

随着肠道微生态科学的发展, 益生菌已让越来越多的IBD尤其是UC患者获益, 但是益生菌治疗IBD尤其是CD的机制尚不清楚, 且粪便菌群移植(FMT)在IBD中的应用还存在较多有待探讨的领域。由于益生菌治疗IBD涉及的机制复杂, 所以临床上较难把控其依据及指征。本文将益生菌治疗IBD的机制分为免疫、微生物、营养和精神心理四大途径进行梳理, 以期为临床选择益生菌提供清晰的思路。

引用

共 23 条

[1]

Bifidobacterium lactis attenuates onset of inflammation in a murine model of colitis [J].

Philippe, David ;

Favre, Laurent ;

Foata, Francis ;

Adolfsson, Oskar ;

Perruisseau-Carrier, Genevieve ;

Vidal, Karine ;

Reuteler, Gloria ;

Dayer-Schneider, Johanna ;

Mueller, Christoph ;

Blum, Stephanie .

WORLD JOURNAL OF GASTROENTEROLOGY, 2011, 17 (04) :459-469

[2]

Probiotic Bio-Three induces Th1 and anti-inflammatory effects in PBMC and dendritic cells [J].

Hua, Man-Chin ;

Lin, Tzou-Yien ;

Lai, Ming-Wei ;

Kong, Man-Shan ;

Chang, Hung-Ju ;

Chen, Chien-Chang .

WORLD JOURNAL OF GASTROENTEROLOGY, 2010, 16 (28) :3529-3540

[3]

Protective Effects of Bifidobacterial Strains Against Toxigenic Clostridium difficile [J].

Wei, Yanxia ;

Yang, Fan ;

Wu, Qiong ;

Gao, Jing ;

Liu, Wenli ;

Liu, Chang ;

Guo, Xiaokui ;

Suwal, Sharmila ;

Kou, Yanbo ;

Zhang, Bo ;

Wang, Yugang ;

Zheng, Kuiyang ;

Tang, Renxian .

FRONTIERS IN MICROBIOLOGY, 2018, 9

[4]

Role of Lactobacillus reuteri in Human Health and Diseases [J].

Mu, Qinghui ;

Tavella, Vincent J. ;

Luo, Xin M. .

FRONTIERS IN MICROBIOLOGY, 2018, 9

[5]

New clinical recommendations for Clostridium difficile [J].

Mushtaq, Ammara .

LANCET INFECTIOUS DISEASES, 2018, 18 (04) :384-384

[6]

The molecular mechanism for activating IgA production by Pediococcus acidilactici K15 and the clinical impact in a randomized trial [J].

Kawashima, Tadaomi ;

Ikari, Naho ;

Kouchi, Tomoko ;

Kowatari, Yasuyuki ;

Kubota, Yoshiro ;

Shimojo, Naoki ;

Tsuji, Noriko M. .

SCIENTIFIC REPORTS, 2018, 8

[7]

Bifidobacterium longum alleviates dextran sulfate sodium-induced colitis by suppressing IL-17A response: involvement of intestinal epithelial costimulatory molecules..[J].Eiji Miyauchi;Tasuku Ogita;Junki Miyamoto;Seiji Kawamoto;Hidetoshi Morita;Hiroshi Ohno;Takuya Suzuki;Soichi Tanabe.PLoS ONE.2018, 11

[8]

Non-digestible oligosaccharides directly regulate host kinome to modulate host inflammatory responses without alterations in the gut microbiota [J].

Wu, Richard Y. ;

Maattanen, Pekka ;

Napper, Scott ;

Scruten, Erin ;

Li, Bo ;

Koike, Yuhki ;

Johnson-Henry, Kathene C. ;

Pierro, Agostino ;

Rossi, Laura ;

Botts, Steven R. ;

Surette, Michael G. ;

Sherman, Philip M. .

MICROBIOME, 2017, 5 :135

[9]

Gut Microbiota Species Can Provoke both Inflammatory and Tolerogenic Immune Responses in Human Dendritic Cells Mediated by Retinoic Acid Receptor Alpha Ligation [J].

Bene, Krisztian ;

Varga, Zsofia ;

Petrov, Viktor O. ;

Boyko, Nadiya ;

Rajnavolgyi, Eva .

FRONTIERS IN IMMUNOLOGY, 2017, 8

[10]

Probiotic Saccharomyces boulardii CNCM I-745 prevents outbreak-associated Clostridium difficile-associated cecal inflammation in hamsters [J].

Koon, Hon Wai ;

Su, Bowei ;

Xu, Chunlan ;

Mussatto, Caroline C. ;

Diana Hoang-Ngoc Tran ;

Lee, Elaine C. ;

Ortiz, Christina ;

Wang, Jiani ;

Lee, Jung Eun ;

Ho, Samantha ;

Chen, Xinhua ;

Kelly, Ciaran P. ;

Pothoulakis, Charalabos .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2016, 311 (04) :G610-G623

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