抗菌肽抑菌机制研究进展

被引:10
作者
黄现青 [1 ]
高晓平 [1 ]
赵改名 [1 ]
李苗云 [1 ]
柳艳霞 [1 ]
张秋会 [1 ]
孙灵霞 [1 ]
袁勇军 [2 ]
机构
[1] 河南农业大学食品科技学院
[2] 浙江万里学院生物与环境学院
关键词
抗菌肽; 机制; 孔洞;
D O I
暂无
中图分类号
Q51 [蛋白质];
学科分类号
摘要
抗菌肽是由各种无脊椎动物、植物和哺乳动物的组织、细胞产生的丰富且分子多样性的一类物质。它们的氨基酸组成、两亲性、阳离子电荷和它们的大小使它们能够粘附或插入到细胞膜中形成孔洞,也就形成所谓的"木桶式"、"地毯式"和"环孔式"的机制。主要介绍几种不同的诱导细菌孔洞形成、细胞死亡的模型及耐药机制。
引用
收藏
页码:62 / 66
页数:5
相关论文
共 19 条
  • [1] Modulation of the Activity of rhanatin by Antimicrobial Peptides. Zhao H,Kinnunen PK. Antimicrobial Agents and Chemotherapy . 2003
  • [2] Capsule Polysaccharide Mediates Bacterial Resistance to Antimicrobial Peptides. Campos M. A,Vargas M. A,Regueiro V,Llompart C. M,Alberti S,Bengoechea J. A. Infection and Immunity . 2004
  • [3] Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis. Wadia J S, Stan R V, Dowdy S F. Nature Medicine . 2004
  • [4] Human hemoglobin-derived peptides exhibit antimicrobial activity: a class of host defense peptides[J] . &nbspJournal of Chromatography B . 2003 (1)
  • [5] Multidimensional signatures in antimicrobial peptides. Yount NY,Yeaman MR. Proceedings of the National Academy of Sciences of the United States of America . 2004
  • [6] Structural features and biological activities of the cathelicidin-derived antimicrobial peptides. Gennaro R,Zanetti M. Biopolymers . 2000
  • [7] The lantibiotic mersacidin inhibits peptidoglycan synthesis by targeting lipid II. Brotz,H,Bierbaum,G,Leopold,K,Reynolds,PE,Sahl,HG. Antimicrobial Agents and Chemotherapy . 1998
  • [8] Membrane thinning effect of the β-sheet antimicrobial protegrin. Heller W T,Waring A J,Lehrer R I, et al. Biochemistry . 2000
  • [9] Human hemoglobin-derived peptides exhibit antimicrobial activity: a class of host defense peptides. Liepke, C,Baxmann, S,Heine, C,Breithaupt, N,St(a|¨)ndker, L,Forssmann, W.G. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci . 2003
  • [10] Defensins: antimicrobial peptides of innate immunity. Ganz T. Nature Reviews Immunology . 2003