小檗碱在溃疡性结肠炎中作用及机制的研究进展

被引：42

作者：

张苏 ^{[1
,2
]}

王志斌 ^{[3
]}

王跃 ^{[1
]}

仝令畅 ^{[3
]}

王荣美 ^{[3
]}

李玲 ^{[3
]}

张立超 ^{[1
]}

机构：

[1] 上海市中医医院药剂科

[2] 宁夏医科大学药学院

[3] 第二军医大学药学院药理教研室

来源：

国际消化病杂志 | 2016年 / 36卷 / 03期

关键词：

溃疡性结肠炎; 小檗碱; 紧密连接; 免疫调节; 氧化应激;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

100806 [中药药理学];

摘要：

溃疡性结肠炎(UC)是一种慢性非特异性肠道炎性疾病,其发病机制可能与遗传、环境、免疫及微生物有关。小檗碱是黄连的主要成分,临床上主要用于抗炎。近年来研究发现小檗碱对UC有良好的疗效,但治疗机制尚不完全清楚,可能通过调整肠道菌群结构、保护肠道屏障功能、调节免疫应答反应、影响氧化应激等来发挥治疗作用,该文就此作一综述,为小檗碱应用于UC治疗提供理论依据。

引用

页码：136 / 138+193 +193

页数：4

共 14 条

[1]

Chemokine and cytokine levels in inflammatory bowel disease patients.[J].Udai P. Singh;Narendra P. Singh;E. Angela Murphy;Robert L. Price;Raja Fayad;Mitzi Nagarkatti;Prakash S. Nagarkatti.Cytokine.2016,

[2]

Berberine ameliorates TNBS induced colitis by inhibiting inflammatory responses and Th1/Th17 differentiation [J].

Li, Chengzhen ;

Xi, Yebin ;

Li, Shan ;

Zhao, Qing ;

Cheng, Wenjing ;

Wang, Zhengting ;

Zhong, Jie ;

Niu, Xiaoyin ;

Chen, Guangjie .

MOLECULAR IMMUNOLOGY, 2015, 67 (02) :444-454

[3]

Effects of Berberine on Cell Cycle; DNA; Reactive Oxygen Species; and Apoptosis in L929 Murine Fibroblast Cells.[J].Manman Gu;Jing Xu;Chunyang Han;Youxi Kang;Tengfei Liu;Yanfei He;Yanfei Huang;Cuiyan Liu;Ciara Hughes.Evidence-Based Complementary and Alternative Medi.2015,

[4]

Lung and Intestine: A Specific Link in an Ulcerative Colitis Rat Model.[J].Yuan Liu;Xin-Yue Wang;Xue Yang;Shan Jing;Li Zhu;Si-Hua Gao;Bj?rn Moum.Gastroenterology Research and Practice.2013,

[5]

Suppressive effect of berberine on experimental dextran sulfate sodium-induced colitis [J].

Hong, Tie ;

Yang, Zhen ;

Lv, Chuan-Feng ;

Zhang, Yu .

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2012, 34 (03) :391-397

[6]

Berberine Ameliorates Pro-inflammatory Cytokine-Induced Endoplasmic Reticulum Stress in Human Intestinal Epithelial Cells In Vitro [J].

Hao, Xianhua ;

Yao, Anlong ;

Gong, Jianfeng ;

Zhu, Weiming ;

Li, Ning ;

Li, Jieshou .

INFLAMMATION, 2012, 35 (03) :841-849

[7]

Oxidative stress and redox signaling mechanisms of inflammatory bowel disease: updated experimental and clinical evidence [J].

Zhu, Hong ;

Li, Y. Robert .

EXPERIMENTAL BIOLOGY AND MEDICINE, 2012, 237 (05) :474-480

[8]

Berberine attenuates pro-inflammatory cytokine-induced tight junction disruption in an in vitro model of intestinal epithelial cells [J].

Li, Ning ;

Gu, Lili ;

Qu, Linlin ;

Gong, Jianfeng ;

Li, Qiurong ;

Zhu, Weiming ;

Li, Jieshou .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2010, 40 (01) :1-8

[9]

Berberine ameliorates TNBS-induced colitis by inhibiting lipid peroxidation; enterobacterial growth and NF-κB activation.[J].In-Ah Lee;Yang-Jin Hyun;Dong-Hyun Kim.European Journal of Pharmacology.2010, 1

[10]

The effect of berberine in vitro on tight junctions in human Caco-2 intestinal epithelial cells [J].

Gu, Lili ;

Li, Ning ;

Li, Qiurong ;

Zhang, Qiang ;

Wang, Chengyang ;

Zhu, Weiming ;

Li, Jieshou .

FITOTERAPIA, 2009, 80 (04) :241-248

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