糖尿病肾病患者血清细胞外基质的变化及其临床意义

被引：3

作者：

王虹 ^{[1
]}

周志雄 ^{[2
]}

周泽美 ^{[3
]}

机构：

[1] 桂阳县人民医院检验科

[2] 湘南学院附属医院检验科

[3] 湖南郴州湘南学院临床检验教研室

来源：

现代生物医学进展 | 2008年 / 05期

关键词：

细胞外基质; 糖尿病肾病; 2型糖尿病;

D O I：

10.13241/j.cnki.pmb.2008.05.043

中图分类号：

R587.2 [糖尿病性昏迷及其他并发症];

学科分类号：

1002 ; 100201 ;

摘要：

目的:探讨2型糖尿病患者血清细胞外基质(ECM)水平与糖尿病肾病(DN)之间的关系。方法:运用放射免疫法检测78例2型糖尿病惠者和25名健康者的血清Ⅳ型胶原(cⅣ)、层粘蛋白(LN)、透明质酸(HA)3种ECM水平。实验分成对照组、非糖尿病肾病组(NDN组)、糖尿病肾病组(DN组)(又分为微量白蛋白尿MA组、临床肾病CDN组)。用直线相关分析糖尿病患者血清cⅣ、LN、HA与其它临床指标之间的相关关系。结果:DN组和NDN组的血清cⅣ、LN水平与对照组间差异有显著性意义,DN组的血清cⅣ、LN水平与NDN组间差异有显著性意义(P<0.01)。DN患者进一步分组后,CDN组的血清cⅣ、LN水平与MA组间差异有显著性意义(P<0.05)。糖尿病患者血清cⅣ、LN水平均分别与空腹血糖(FPG)、舒张压和病程呈正相关。结论:2型糖尿病患者血清cⅣ、LN水平高于正常人,而且与DN的发生、发展有密切的关系。

引用

页码：897 / 899+907 +907

页数：4

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