NMDA受体在脑缺血中的作用和机制的研究进展

被引：6

作者：

徐春红

曹红

机构：

[1] 温州医学院附属二院麻醉科

来源：

国际麻醉学与复苏杂志 | 2007年 / 01期

关键词：

NMDA受体; 脑缺血;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

1002 ;

摘要：

脑缺血时,N-甲基-D-天门冬氨酸受体(NMDA-R),尤其是NR2B通过酪氨酸或丝/苏氨酸磷酸化作用其结构和功能发生改变,激活下游细胞信号传导通路,诱导神经元兴奋毒性、细胞凋亡。其受体和非受体酪氨酸激酶途径受金属离子、细胞因子、氧化应激、原癌基因等的调节。NMDA-R拮抗剂单独用药时可产生封顶效应,而联合用药可产生更强的神经元保护作用。

引用

页码：88 / 91

共 8 条

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