肿瘤患者外周血循环血管内皮细胞数量与血清VEGF水平的关系

被引：21

作者：

李慧

张澎

任秀宝

刘虹

郝希山

机构：

[1] 天津医科大学附属肿瘤医院

来源：

中国肿瘤生物治疗杂志 | 2003年 / 03期

基金：

天津市自然科学基金;

关键词：

肿瘤; 循环血管内皮细胞; 循环血管内皮前体细胞; 血管内皮生长因子;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

摘要：

目的 :分析实体瘤患者外周血中的循环血管内皮细胞 (circulatingendothelialcells,CECs)及血管内皮前体细胞 (cir culatingendothelialprecursors ,CEPs) ,并比较与正常人的差异。方法 :流式细胞法检测 5 7肿瘤患者及 15例正常人外周血中的CECs和CEPs ,ELISA法检测血清中血管生成相关因子VEGF和bFGF的表达水平。结果 :肿瘤患者外周血CECs及CEPs分别为 (0 .378± 0 .0 4 7) %和 (0 .0 5 9± 0 .0 13) % ,血清VEGF ,bFGF分别为 (2 95 .5 8± 5 9.5 6 )ng/L和 (2 8.73± 7.4 0 )ng/L ,均高于正常对照组 (P <0 .0 5 )。血管内皮及其前体细胞的数量与血清VEGF ,bFGF水平相关。结论 :实体瘤患者外周血中循环血管内皮及其前体细胞、血管内皮生长因子均高于正常人 ;VEGF和bFGF可能参与了血管内皮干 /祖细胞的动员过程。

引用

页码：194 / 197

页数：4

共 17 条

[1]

The role of angiogenesis in tumor growth. Folkman J. Seminars in Cancer Biology . 1992

[2]

Angiogenesis in cancer, vascular, rheumatoid, and other diseases. Folkman J. Nature Medicine . 1995

[3]

Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells responsible for neovascularization. Takahashi T,Kalka C,Masuda H,et al. Nature Medicine . 1999

[4]

Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopoiesis by recruitment of vasculogenic and hematopoietic stem cells. Hattori K,Dias S,Heissig B,et al. The Journal of Experimental Medicine . 2001

[5]

Mobilization of endothelial progenitor cells in patients with acute myocardial infarction. Shintani S,Murohara T,Ikeda H,et al. Circulation . 2001

[6]

Evidence for circulating bone marrow-derived endothelial cells. Shi Q,Raffi S,Wu WH,et al. Blood . 1998

[7]

Impaired recruitment of bone marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Lyden D,Hattori K,Dias S,et al. Nature Medicine . 2001

[8]

Isolation of putative progenitor endothelial cells for angiogenesis. Asahara T,Murohara T,Sullivan A,et al. Science . 1997

[9]

VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells. Asahara T,Takahashi T,Masuda H,et al. EMBO Journal . 1999

[10]

Vascular endothelial growth factor(165) gene transfer augments circulating endothelial progenitor cells in human subjects. Kalka C,Masuda H,Takahashi T,et al. Circulation Research . 2000

← 1 2 →