七氟烷预处理对急性缺氧小鼠脑氧化应激的影响

被引：2

作者：

马达

汪梦霞

李雅兰

梁云洁

王成果

机构：

[1] 暨南大学附属第一医院麻醉科

来源：

暨南大学学报(自然科学与医学版) | 2013年 / 34卷 / 04期

基金：

广东省科技计划;

关键词：

七氟烷; 预处理; 缺氧; 脑保护; 氧化应激;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100103 [病原生物学];

摘要：

目的:观察七氟烷预处理对急性缺氧小鼠脑氧化应激的影响,并探讨其与预处理的时间、剂量的关系。方法:60只雄性C57BL/6J小鼠随机分为6组:对照组（Control）、急性缺氧组（H组,6.5%O2,24 h）、2%Sevo 30 min+H组、2%Sevo 60 min+H组、4%Sevo 30 min+H组、Propofol+H组。按试剂盒说明检测脑匀浆丙二醛（MDA）含量及超氧化物岐化酶（SOD）、谷胱甘肽过氧化物酶（GPx）活性。结果:与H组比较,各七氟烷预处理组脑内MDA水平下降,并在2%Sevo 60 min+H组、4%Sevo 30 min+H组降低显著,Propofol+H组则无意义;GPx活性在各七氟烷预处理组有所升高,在4%Sevo 30 min+H组上升显著,Propofol+H组GPx活性下降,但不明显;与预计相反,各预处理使SOD活性显著降低。结论:七氟烷预处理减轻脑氧化应激而具有脑保护作用,并与时间、剂量相关。

引用

页码：405 / 409+436 +436

页数：6

共 14 条

[1]

现代麻醉学.[M].庄心良;曾因明等主编.人民卫生出版社.2003,

[2]

Involvement of oxidative stress in hypoxia-induced blood–brain barrier breakdown.[J].Abraham Al Ahmad;Max Gassmann;Omolara O. Ogunshola.Microvascular Research.2012, 2

[3]

Naringenin and quercetin reverse the effect of hypobaric hypoxia and elicit neuroprotective response in the murine model.[J].Aditi Sarkar;M. Sonia Angeline;Kushi Anand;Rashmi K Ambasta;Pravir Kumar.Brain Research.2012,

[4]

Long-term ginsenoside administration prevents memory loss in aged female C57BL/6J mice by modulating the redox status and up-regulating the plasticity-related proteins in hippocampus.[J].H.F. Zhao;Q. Li;Y. Li.Neuroscience.2011,

[5]

Sevoflurane Preconditioning Induces Neuroprotection Through Reactive Oxygen Species-Mediated Up-Regulation of Antioxidant Enzymes in Rats [J].

Yang, Qianzi ;

Dong, Hui ;

Deng, Jiao ;

Wang, Qiang ;

Ye, Ruidong ;

Li, Xuying ;

Hu, Sheng ;

Dong, Hailong ;

Xiong, Lize .

ANESTHESIA AND ANALGESIA, 2011, 112 (04) :931-937

[6]

Neuroprotective role of Bacopa monnieri extract in epilepsy and effect of glucose supplementation during hypoxia:: Glutamate receptor gene expression [J].

Paulose, C. S. ;

Chathu, Finla ;

Khan, S. Reas ;

Krishnakumar, Amee .

NEUROCHEMICAL RESEARCH, 2008, 33 (09) :1663-1671

[7]

Effect of heavy metal stress on proline; malondialdehyde; and superoxide dismutase activity in the cyanobacterium Spirulina platensis -S5.[J].Meenakshi Choudhary;Umesh Kumar Jetley;Mohammed Abash Khan;Sunaina Zutshi;Tasneem Fatma.Ecotoxicology and Environmental Safety.2006, 2

[8]

Free radicals, metals and antioxidants in oxidative stress-induced cancer [J].

Valko, M ;

Rhodes, CJ ;

Moncol, J ;

Izakovic, M ;

Mazur, M .

CHEMICO-BIOLOGICAL INTERACTIONS, 2006, 160 (01) :1-40

[9]

Sevoflurane immediate preconditioning alters hypoxic membrane potential changes in rat hippocampal slices and improves recovery of CA1 pyramidal cells after hypoxia and global cerebral ischemia.[J].J. Wang;B. Lei;S. Popp;F. Meng;J.E. Cottrell;I.S. Kass.Neuroscience.2006, 3

[10]

Hypobaric hypoxia-induced dendritic atrophy of hippocampal neurons is associated with cognitive impairment in adult rats.[J].A.D.J. Titus;B.S. Shankaranarayana Rao;H.N. Harsha;K. Ramkumar;B.N. Srikumar;S.B. Singh;S. Chattarji;T.R. Raju.Neuroscience.2006, 1

← 1 2 →