三乙酰莽草酸对局灶性脑缺血再灌注后脑组织损伤和血液流变学的作用(英文)

被引：3

作者：

种兆忠

孙建宁

徐秋萍

机构：

[1] 北京中医药大学药理学教研室!北京,北京中医药大学药理学教研室!北京,北京中医药大学药理学教研室!北京

来源：

中国药理学与毒理学杂志 | 2001年 / 01期

关键词：

三乙酰莽草酸; 脑缺血; 脑梗死; 再灌注损伤; 红细胞变形性; 红细胞聚集; 血液粘度; 尼莫地平;

D O I：

暂无

中图分类号：

R743 [脑血管疾病];

学科分类号：

摘要：

研究了三乙酰莽草酸 (TSA)对局灶性脑缺血再灌注后脑组织损伤保护作用及对血液流变学变化的影响 .线栓塞法阻断右侧大脑中动脉 3h ,然后将线抽出恢复血流 .再灌注 2 1h后 ,脑梗死范围达对侧半球的 ( 36± 8) % .脑缺血开始和缺血后 60min分别igTSA 10 0mg·kg- 1,可使脑梗死范围减少至对侧半球的 ( 2 7± 8) % (P <0 .0 5) ,并降低大鼠的神经症状评分 .同样时间ig尼莫地平 5mg·kg- 1也可减少脑梗死范围 ,降低神经症状评分 .2 4h脑缺血再灌后红细胞变形能力下降 ,红细胞聚集程度 ,血液粘度及血浆粘度皆明显提高 .TSA 10 0mg·kg- 1组红细胞聚集 ,低切变率 ( 5- 1s- 1)下的血液粘度和血浆粘度基本降至正常对照组水平 ,但红细胞变形能力仍有一定降低 .尼莫地平组可见高切变率 ( 2 0 0 -30s- 1)下的全血粘度降低 .结果表明 ,TSA对局灶性脑缺血再灌注引起的脑损伤有一定的保护作用 ,并能改善血液流变学状态

引用

页码：1 / 5

页数：5

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