他汀类药物在治疗非酒精性脂肪肝病中的研究进展

被引：26

作者：

陈思

赵金珍

胡晶

银孟卓

郭志刚

机构：

[1] 南方医科大学南方医院惠侨医疗中心

来源：

中国动脉硬化杂志 | 2017年 / 25卷 / 03期

基金：

广东省自然科学基金;

关键词：

他汀类药物; 非酒精性脂肪肝病; 心血管疾病; 肝脂肪变性; 肝纤维化;

D O I：

暂无

中图分类号：

R575.5 [肝代谢障碍];

学科分类号：

100201 [内科学];

摘要：

近年来,非酒精性脂肪肝病逐渐成为国内肝病相关死亡率的主要因素。非酒精性脂肪肝病的发病机制主要与代谢综合征相关,其危险因素主要包括肥胖、2型糖尿病、脂代谢异常等,这些危险因素与心血管疾病密切相关,心血管疾病死亡率也成为非酒精性脂肪肝病首要的死亡原因。他汀类药物是最主要的降脂药物,有证据表明,非酒精性脂肪肝病患者使用他汀类药物降脂治疗不仅能有效降低肝脏转氨酶水平,降低心血管疾病病死率,而且能有效减轻肝脏脂肪变性程度,同时可能对延缓肝脏纤维化有一定的疗效。

引用

页码：297 / 303

页数：7

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