异常凝血酶原测定对原发性肝癌的诊断价值

被引：8

作者：

殷正丰

吴孟超

机构：

[1] 长海医院肝胆外科研究所

来源：

第二军医大学学报 | 1988年 / 03期

关键词：

异常凝血酶原; 甲胎蛋白; 肿瘤标记物; 肝癌; 诊断;

D O I：

10.16781/j.0258-879x.1988.03.002

中图分类号：

学科分类号：

摘要：

采用放射火箭电泳自显影法,测定了98例经病理证实的HCC和181例其他疾病患者血浆异常凝血酶原含量。在98例HCC中,68例该值≥250 μg/L,阳性率为69.4％,显著高于其他各组。异常凝血酶原与AFP含量无明显相关(r-0.317)。AFP低浓度和阴性HCC的异常凝血酶原阳性率分别为68.8％和65.5％。两个指标联合检测,可使HCC和小肝癌的检出率分别提高到84.7％和84.2％。结果表明;血浆异常凝血酶原测定具有辅助AFP诊断HCC的临床价值,对HCC与慢性肝病及良性肝占位性病变的鉴别诊断亦有帮助。

引用

页码：203 / 207+294 +294-295

页数：7

共 10 条

[1]

Abnormal prothrombin in the plasma of rats carrying hepatic tumors. Shah DV,et al. Blood . 1987

[2]

A simple and rapid test for PIVKA-Ⅱ in plasma. Meguro T,et al. Thrombosis Research . 1982

[3]

A new method to asaay des γ-sarboxy-prothrombin results obtained in 76 cases of hepatocellular carcimoma. Soulier JP,et al. Gastroenterologia . 1986

[4]

Hepatic vitamin K dependent carboxylation of bloodclotting proteins. Liebman HA,et al. Hepatology . 1982

[5]

Production of abnormal prothrombin(des γ-carboxy prothrombin)oy hepatocellular carcinoma: A clinical and experimental stady. Okuda H,et al. Journal of Hepatology . 1987

[6]

Specificity of increased des-gamma-carboxyprothrombin in hepatocellular carcinoma after vitamin K1 injection. Lefrere JJ,et al. Journal of Hepatology . 1987

[7]

Clinical evaluation of ??plasma abnormal prothrombin (PIVKA-Ⅱ) in patients with hepatocellular carcinoma. Fujiyama S,et al. Hepato Gastroenterology . 1986

[8]

Detection of vitamin K deticiency by use of an enzyme-linked immunosorbent assay for circulating abnormal prothrombin. Motohara K,et al. Pediatric Research . 1985

[9]

Quantitative estimation of proteins by elect ophoresis in agarose gel containing antibodies. Laurell CB. Analytical Biochemistry . 1966

[10]

Des-γ-carboxy (abnoremal) prothrombin as a serum marker of primary hepatocellular carcinoma. Liebman HA,et al. The New England Journal of Medicine . 1984

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