他克莫司产生菌的选育和生产工艺研究

被引:6
作者
朱健
谢祥茂
陈俊勇
机构
[1] 杭州华东医药集团公司生物工程研究所
[2] 杭州华东医药集团公司生物工程研究所 浙江杭州
[3] 浙江杭州
关键词
他克莫司; 免疫抑制剂; 菌种诱变; 发酵; 提取;
D O I
暂无
中图分类号
Q939.97 [工业微生物学];
学科分类号
082203 ;
摘要
产他克莫司的原始菌株Streptomyces hzsw-1-25经紫外、60Co、HNO2等方法诱变,筛选得高产突变菌株hzsw-8-1123,优化发酵培养基后,进行摇瓶和2m3罐的发酵试验,并研究了产物的分离提取工艺。
引用
收藏
页码:207 / 210
页数:4
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