丙酮丁醇发酵菌的分子遗传改造

被引:10
作者
杨明 [1 ]
刘力强 [1 ]
牛昆 [1 ]
贾娟娟 [1 ]
李寅 [2 ]
张延平 [2 ]
王正品 [1 ]
机构
[1] 华北制药集团生物燃料研究所
[2] 中国科学院微生物研究所
关键词
丁醇; 丙酮丁醇梭菌; 拜氏梭菌; 基因工程; 分子遗传学;
D O I
10.13523/j.cb.20091021
中图分类号
TQ923 [发酵法制高级醇及多元醇];
学科分类号
081703 ; 082203 ;
摘要
丙酮丁醇梭菌及拜氏梭菌是重要的ABE(丙酮、丁醇和乙醇)工业生产菌株,其发酵产物中的丙酮和丁醇均为重要的化工原料,汽车发动机试验证明丁醇还是一种性能优于乙醇的极具潜力的生物燃料和燃料添加剂。随着新生物技术的不断发展及工业生产的需求,遗传工程改造不断应用于丙酮丁醇生产菌株。在前人研究及工业实践的基础上,对丙酮丁醇生产菌株的遗传特性及其分子遗传改造取得的进展进行了详细概述。
引用
收藏
页码:109 / 114
页数:6
相关论文
共 29 条
[1]   Metabolic engineering of Escherichia coli for 1-butanol and 1-propanol production via the keto-acid pathways [J].
Shen, C. R. ;
Liao, J. C. .
METABOLIC ENGINEERING, 2008, 10 (06) :312-320
[2]  
Butanol Tolerance in a Selection of Microorganisms[J] . Eric P. Knoshaug,Min Zhang. &nbspApplied Biochemistry and Biotechnology . 2009 (1)
[3]   Metabolic pathways of clostridia for producing butanol [J].
Gheshlaghi, R. ;
Scharer, J. M. ;
Moo-Young, M. ;
Chou, C. P. .
BIOTECHNOLOGY ADVANCES, 2009, 27 (06) :764-781
[4]  
细菌的有机溶剂耐受机制[J]. 王鑫昕,王少华,李维,李寅,张延平. 生物工程学报. 2009(05)
[5]  
Continuous cultures of Clostridium acetobutylicum: culture stability and low-grade glycerol utilisation[J] . José Carlos Andrade,Isabel Vasconcelos. &nbspBiotechnology Letters . 2003 (2)
[6]  
Production of butanol from starch-based waste packing peanuts and agricultural waste[J] . T W Jesse,T C Ezeji,N Qureshi,H P Blaschek. &nbspJournal of Industrial Microbiology & Biotechnology . 2002 (3)
[7]   THE GENETIC-ENGINEERING OF MICROBIAL SOLVENT PRODUCTION [J].
WOODS, DR .
TRENDS IN BIOTECHNOLOGY, 1995, 13 (07) :259-264
[8]  
Inactivation of an aldehyde/alcohol dehydrogenase gene from Clostridium acetobutylicum ATCC 824[J] . Edward M. Green,George N. Bennett. &nbspApplied Biochemistry and Biotechnology . 1996 (1)
[9]  
Acetone butanol ethanol (ABE) production from concentrated substrate: reduction in substrate inhibition by fed-batch technique and product inhibition by gas stripping[J] . T. C. Ezeji,N. Qureshi,H. P. Blaschek. &nbspApplied Microbiology and Biotechnology . 2004 (6)
[10]   Transcriptional analysis of product-concentration driven changes in cellular programs of recombinant Clostridium acetobutylicum strains [J].
Tummala, SB ;
Junne, SG ;
Paredes, CJ ;
Papoutsakis, ET .
BIOTECHNOLOGY AND BIOENGINEERING, 2003, 84 (07) :842-854