缺血后处理对缺血再灌注大鼠心肌梗死和心肌细胞凋亡的作用(英文)

被引：13

作者：

李源

陶凌

臧益民

高峰

机构：

[1] 第四军医大学西京医院老年病科

[2] 第四军医大学基础部生理学教研室

来源：

第四军医大学学报 | 2002年 / 18期

关键词：

缺血后处理; 缺血/再灌注; 心肌细胞凋亡;

D O I：

暂无

中图分类号：

R542.22 [];

学科分类号：

摘要：

目的　观察在体情况下缺血后处理 (IPC)对兔心肌梗死范围及缺血心肌细胞凋亡的影响 ,并与缺血预处理 (IP)心脏保护作用比较 .方法　采用兔心肌缺血 /再灌注模型 ,在缺血后、再灌注前多次短暂再灌 /停灌处理 .以 Even's blue-TTC法检测心肌梗死范围 ,TU NEL方法检测缺血心肌细胞凋亡 .结果　与对照组相比 ,缺血后处理明显减小心肌梗死范围 (12 .5± 5 .4%vs对照组 2 6 .7± 6 .7%,P<0 .0 1) ,缺血区心肌凋亡指数明显下降 (14.6± 7.4vs对照组 30 .4± 12 .3,P<0 .0 5 ) .结论　对于已缺血心肌 ,再灌前予多次短暂复灌、停灌处理具有与 IP类似缩小心梗范围作用 ,IPC对缺血心肌的保护效应可能与其抑制缺血心肌细胞凋亡有关 .

引用

页码：1690 / 1693

页数：4

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