免疫毒素研究及临床应用进展 (一)临床前研究

被引:2
作者
李俊植
机构
[1] 长春生物制品研究所长春
关键词
免疫毒素和/或融合蛋白毒素; 抗肿瘤靶向药物; 临床研究;
D O I
10.13200/j.cjb.2004.01.60.lijzh.022
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
免疫毒素和 /或融合蛋白毒素 ,是用化学方法或基因工程方法将肿瘤选择性配体与经修饰的多肽毒素共价连接而成的肿瘤治疗药物。这种药物是通过抑制肿瘤细胞蛋白质合成和诱导细胞凋亡而达到杀伤肿瘤细胞的目的。二十多年来 ,人们已进行了很多临床试验 ,但在药理学及毒理学方面的诸多问题尚未得到解决。令人兴奋的是 ,美国FDA首次批准了ONTAK(DAB389 IL2 )用于治疗人皮肤T细胞淋巴瘤 ,还有很多正在进行I/II期临床试验的其它靶向药物 ,均已呈现出显著的抗肿瘤作用 ,预期这些药物在未来的十年将得到更长足的发展。
引用
收藏
页码:60 / 63
页数:4
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