AIM:The Maastricht Ⅱ criteria suggest the use of amoxicillinand darithromycin in addition to a proton pump inhibitor over7-10 d as a first line therapy in the eradication of Helicobacterpylori(Hpylori).For each proton pump inhibitor,various ratesof eradication have been reported.The present study was tocompare the efficacy of different proton pump inhibitors likeomeprazole,lansoprazole and pantoprazole in combinationwith amoxicillin and clarithromycin in the first line eradicationof Hpy/onand to investigate the success of Hpyloneradicationin our district.METHODS:A total of 139 patients were included having aHeelicobacter pylori(+) gastroduodenal disorders diagnosedby means of histology and urease test.Besides amoxicillin(1000mg twice a day) and clarithromycin (500mg twicea day),they were randomized to take omeprazole (20mgtwice a day),or lansoprazole (30mg twice a day),orpantoprozole (40mg twice a day) for 14 d,Four weeksafter the therapy,the eradication was assessed by meansof histology and urease test.It was evaluated as eradicatedif the H pylori was found negative in both.The complaints(pain in epigastrium,nocturnal pain,pyrosis and bloating)were graded in accordance with the Licert scale.Thecompliance of the patients was recorded.RESULTS:The eradication was found to be 40.8% in theomeprazole group,43.5% in the lansoprazole group and47.4% in the pantoprazole group.Sixty-three out of 139patients (45%) had eradication.No statistically significantdifference was observed between the groups.Significantimprovements were seen in terms of the impact on thesymptom scores in each group.CONCLUSION:There was no difference betweenomeprazole,lansoprazole and pantoprazole in H pylorieradication,and the rate of eradication was as low as 45%.Symptoms were improved independent of the eradication ineach treatment group.The low eradication rates suggestthat the antibiotic resistance or the genetic differences ofthe microorganism might be in effect.Further studies arerequired to verify these suggestions.
