17β-雌二醇对卵巢切除小鼠海马内脑源性神经营养因子及神经营养因子 3表达的影响(英文)

被引：4

作者：

聂伟

张永祥

周文霞

机构：

[1] 北京药理毒理研究所,北京药理毒理研究所,北京药理毒理研究所北京,北京,北京

来源：

中国药理学与毒理学杂志 | 2002年 / 04期

关键词：

卵巢切除术; 雌二醇; 脑源性神经营养因子; 神经营养因子3;

D O I：

暂无

中图分类号：

R965 [实验药理学];

学科分类号：

100602 ; 100706 ;

摘要：

目的　为确定雌激素可能具有的神经营养调节作用。方法　采用蛋白质印迹法检测上述指标的变化。结果　与卵巢未切除对照组相比 ,小鼠卵巢切除 10周后海马内脑源性神经营养因子 (BDNF)表达水平明显下降 ,给予 17β 雌二醇 (2 .4或 4 .8μg·d- 1,sc ,连续 12周 )替代具有明显的改善作用 (P <0 .0 1)。但卵巢切除及 17β 雌二醇替代对海马内神经营养因子 3表达水平无明显影响。结论　海马内BDNF表达水平的改变与雌激素缺乏具有密切关系。雌激素对调节海马内BDNF水平具有重要作用。

引用

页码：246 / 249

页数：4

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