间充质干细胞修复骨关节炎软骨损伤的临床应用意义

被引：12

作者：

张爽 ^{[1
]}

刘石 ^{[1
]}

汪宇峰 ^{[1
]}

吕婵 ^{[1
]}

李保玲 ^{[1
]}

王萍 ^{[1
]}

丛军 ^{[1
]}

朱志强 ^{[2
]}

机构：

[1] 哈尔滨体育学院科学研究中心

[2] 哈尔滨体育学院

来源：

中国组织工程研究 | 2018年 / 22卷 / 33期

关键词：

骨关节炎; 细胞移植; 综述; 组织工程; 间充质干细胞; 软骨损伤; 细胞治疗; 移植; 细胞分化; 透明质酸; 组织修复;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

背景:关节软骨退变是临床和基础水平研究的持续挑战。由于受损部位软骨细胞再生能力有限,因而干细胞为基础治疗方案已成为关节软骨修复的新型治疗方法。间充质干细胞因具有多潜能性及免疫抑制等特性而成为组织工程研究的首选资源。目的:总结近年来不同组织来源间充质干细胞在软骨损伤修复方面的应用效果。方法:以"间充质干细胞,软骨损伤修复,骨关节炎"为中文检索词,"mesenchymal stem cells,cartilage repair,osteoarthritis"为英文检索词,在PubMed、WebofScience及中国知网数据库中检索建库至2018年关于间充质干细胞用于软骨损伤治疗的文献。初步共检索到168篇文献,阅读全文后,按照入选标准进行评估,最终选取59篇文献,其中英文文献57篇,中文文献2篇。结果与结论:(1)间充质干细胞具有自我更新能力并可分化为多种中胚层谱系细胞,如成骨细胞、软骨细胞、脂肪细胞,心肌细胞和血管细胞等;(2)间充质干细胞的免疫调节作用和再生能力能够调节骨关节炎中关节合成代谢和分解代谢过程的失衡;(3)当前,虽然已有大量间充质干细胞用于软骨损伤修复的临床研究,但其修复机制仍不明确,有待进一步探究;(4)间充质干细胞治疗效果受细胞来源、移植细胞数量及注射方式影响。

引用

页码：5379 / 5385

页数：7

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