补阳还五汤联合依达拉奉对小鼠急性脑缺血再灌注损伤的神经保护作用

被引：9

作者：

钟芳芳

吴承龙

孙新芳

章燕幸

机构：

[1] 绍兴市人民医院

来源：

中国现代应用药学 | 2016年 / 33卷 / 03期

关键词：

补阳还五汤; 依达拉奉; 脑缺血再灌注; 细胞凋亡;

D O I：

10.13748/j.cnki.issn1007-7693.2016.03.008

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

目的研究补阳还五汤联合依达拉奉对小鼠脑缺血再灌注损伤模型的保护作用。方法改良线栓法建立小鼠大脑中动脉缺血再灌注模型。小鼠随机分为假手术组、模型组、补阳还五汤组、依达拉奉组和补阳还五汤+依达拉奉组。术后1,3,7 d观察治疗后各组小鼠神经功能缺损评分。术后7 d,比较各组脑梗死体积大小,TUNEL法检测细胞凋亡。结果与假手术组比较,模型组小鼠神经缺损评分、脑梗死体积、凋亡细胞数均显著增加(P<0.01)。与模型组比较,各用药组神经缺损评分、脑梗死体积、凋亡细胞数均显著减少(P<0.05),且联合用药组以上指标均显著好于单用药组。结论补阳还五汤与依达拉奉联合用药对小鼠脑缺血再灌注损伤有协同神经保护作用,比单药使用更有效地抑制细胞凋亡。

引用

页码：293 / 297

页数：5

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