脑梗死患者血清褪黑素节律改变与卒中后日间过度倦睡

被引:18
作者
吴士文
杨光
金民
郭军红
于生元
机构
[1] 北京市中国人民解放军总医院神经内科
[2] 徐州医学院附属淮阴医院神经内科
关键词
褪黑素; 脑梗死; 脑出血; 日间过度倦睡;
D O I
暂无
中图分类号
R743.31 [短暂性脑缺血];
学科分类号
摘要
目的动态观察脑梗死患者急性期血清褪黑素(melatonin,MT)的节律变化,及其与卒中后睡眠障碍的关系。方法放免法测定20例卒中患者发病后2d内、第7天、第14天的0200、0800时血清MT的浓度;18例对照组采用同样的方法测定其血清MT浓度。结果对照组、卒中组(2d内、7、14d)夜间MT浓度分别为86.14±24.94,54.08±33.33,61.93±28.44,65.81±32.15pg/L,卒中组明显低于对照组,梗死第7天后夜间MT浓度较发病1~2d显著增高;卒中组日间MT浓度与对照组之间差异无统计学意义;20例患者中3例出现日间过度倦睡,与无倦睡组相比,其夜间MT浓度更低。结论卒中患者仍有夜高昼低的MT分泌节律,但其夜间MT浓度显著下降,伴有日间过度倦睡者下降更显著。
引用
收藏
页码:58 / 60
页数:3
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