炎症因子与炎症因子相关信号通路在膝骨关节炎中的调控机制研究进展

被引：151

作者：

贺娟娟 ^{[1
]}

颜春鲁 ^{[1
,2
]}

安方玉 ^{[1
,2
]}

李盛华 ^{[1
]}

张艳霞 ^{[1
,2
]}

赵磊 ^{[3
]}

杨晓蓉 ^{[1
]}

成新平 ^{[1
]}

靳安顺 ^{[1
]}

机构：

[1] 甘肃中医药大学临床医学院

[2] 敦煌医学与转化教育部重点实验室

[3] 甘肃省高校中(藏)药化学与质量研究省级重点实验室

来源：

中国临床药理学杂志 | 2019年 / 35卷 / 12期

关键词：

膝骨关节炎; 炎症因子; 信号通路; 细胞因子;

D O I：

10.13699/j.cnki.1001-6821.2019.12.025

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

膝骨关节炎(KOA)是一种主要累及人体膝关节软骨的常见退行性疾病,其发生发展是由多因素相互作用的复杂过程。近年来,细胞因子及其与细胞因子相关的信号通路在KOA的发生、发展的研究中备受关注,并取得了一定的进展。本文将对与KOA的发生有密切关系的炎症因子及信号通路两个方面对膝骨性关节炎的研究进展作一综述。

引用

页码：1308 / 1311

页数：4

共 28 条

[1]

Shikonin inhibits inflammation and chondrocyte apoptosis by regulation of the PI3K/Akt signaling pathway in a rat model of osteoarthritis [J].

Fu, Daijie ;

Shang, Xifu ;

Ni, Zhe ;

Shi, Guoguang .

EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2016, 12 (04) :2735-2740

[2]

A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis [J].

Liu, Zhaoyang ;

Chen, Jianquan ;

Mirando, Anthony J. ;

Wang, Cuicui ;

Zuscik, Michael J. ;

O'Keefe, Regis J. ;

Hilton, Matthew J. .

SCIENCE SIGNALING, 2015, 8 (386)

[3]

Berberine ameliorates cartilage degeneration in interleukin-1β-stimulated rat chondrocytes and in a rat model of osteoarthritis via Akt signalling [J].

Zhao, Honghai ;

Zhang, Tongen ;

Xia, Chun ;

Shi, Lei ;

Wang, Shaojie ;

Zheng, Xinpeng ;

Hu, Tianhui ;

Zhang, Bing .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2014, 18 (02) :283-292

[4]

Serum cartilage oligomeric matrix protein (COMP) in knee osteoarthritis: A novel diagnostic and prognostic biomarker [J].

Verma, Priyanka ;

Dalal, Krishna .

JOURNAL OF ORTHOPAEDIC RESEARCH, 2013, 31 (07) :999-1006

[5]

Interaction of Wnt/β-catenin and notch signaling in the early stage of cardiac differentiation of P19CL6 cells [J].

Li, Binhong ;

Jia, Zhuqing ;

Wang, Tao ;

Wang, Weiping ;

Zhang, Chenguang ;

Chen, Ping ;

Ma, Kangtao ;

Zhou, Chunyan .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2012, 113 (02) :629-639

[6]

Recent advances in biomarkers in osteoarthritis [J].

Patra, Debabrata ;

Sandell, Linda J. .

CURRENT OPINION IN RHEUMATOLOGY, 2011, 23 (05) :465-470

[7]

Signaling of interleukin-17 family cytokines in immunity and inflammation.[J].Seon Hee Chang;Chen Dong.Cellular Signalling.2010, 7

[8]

Epidermal growth factor increases prostaglandin E2 production via ERK1/2 MAPK and NF-κB pathway in fibroblast like synoviocytes from patients with rheumatoid arthritis [J].

Nah, Seong-Su ;

Won, Hye-Jin ;

Ha, Eunyoung ;

Kang, Insug ;

Cho, Hong Yon ;

Hur, Sook-Jin ;

Lee, Sang-Hoon ;

Baik, Hyung Hwan .

RHEUMATOLOGY INTERNATIONAL, 2010, 30 (04) :443-449

[9]

Tumour necrosis factor-α (TNF-α) increases nuclear factor κB (NFκB) activity in and interleukin-8 (IL-8) release from bovine mammary epithelial cells.[J].D.C. Fitzgerald;K.G. Meade;A.N. McEvoy;L. Lillis;E.P. Murphy;D.E. MacHugh;A.W. Baird.Veterinary Immunology and Immunopathology.2007, 1

[10]

Differentiation of human mesenchymal stem cells and articular chondrocytes: Analysis of chondrogenic potential and expression pattern of differentiation-related transcription factors [J].

Karlsson, Camilla ;

Brantsing, Camilla ;

Svensson, Teresia ;

Brisby, Helena ;

Asp, Julia ;

Tallheden, Tommi ;

Lindahl, Anders .

JOURNAL OF ORTHOPAEDIC RESEARCH, 2007, 25 (02) :152-163

← 1 2 3 →