线粒体功能障碍与帕金森病关系的研究进展

被引：11

作者：

李玉娟

王丹巧

机构：

[1] 中国中医科学院医学实验中心

来源：

中国药理学与毒理学杂志 | 2013年 / 27卷 / 04期

关键词：

帕金森病; 线粒体; parkin; PTEN诱导的激酶1; DJ-1; α突触核蛋白;

D O I：

暂无

中图分类号：

R742.5 [震颤麻痹综合征];

学科分类号：

1002 ;

摘要：

帕金森病是一种多因素引发的神经退行性疾病,表现为黑质纹状体致密部多巴胺能神经元退行性病变。越来越多的研究表明,线粒体功能障碍在帕金森病形成过程中起重要作用。线粒体蛋白parkin,PTEN诱导的激酶1和DJ-1通路的变化以及α突触核蛋白的过表达均是引起线粒体功能障碍的主要原因。目前,研究人员正在努力寻找能够改善线粒体功能从而治疗帕金森病的药物,有些药物已进入临床试验阶段。

引用

页码：727 / 730

页数：4

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