黑素细胞内酪氨酸酶翻译后加工运输障碍与某些色素病的关系

被引:3
作者
孙秀坤
许爱娥
机构
[1] 杭州市第三人民医院皮肤科
关键词
酪氨酸酶; 蛋白; 运输; 色素失凋症;
D O I
暂无
中图分类号
R758.4 [代谢障碍性皮肤病];
学科分类号
100206 ;
摘要
酪氨酸酶翻译后加工运输障碍见于许多色素缺失性疾患。酪氨酸酶内质网滞留与某些黑素瘤的无色素表型有关,同时也是泛发性白化病 1型 /3型的亚细胞病理改变。酪氨酸酶从高尔基体到黑素体的运输过程中,不同环节发生障碍导致不同疾病,从泛发性白化病 2型 /4型到某些白化病综合征。酪氨酸酶及其他黑素相关蛋白翻译后加工运输障碍与疾病的关系,对包括白癜风在内的色素性皮肤病的发病机制研究有一定提示,也给色素性皮肤病的治疗开拓新的领域。
引用
收藏
页码:50 / 52
页数:3
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