糖尿病周围神经病变疼痛机制研究进展

被引：11

作者：

王汉兵 ^{[1
]}

王焱林 ^{[2
]}

杨承祥 ^{[1
]}

机构：

[1] 中山大学附属佛山医院麻醉科

[2] 武汉大学附属中南医院麻醉科

来源：

国际麻醉学与复苏杂志 | 2007年 / 02期

关键词：

糖尿病; 神经病变; 背根神经节; 疼痛;

D O I：

暂无

中图分类号：

R587 [胰岛疾病];

学科分类号：

1002 ; 100201 ;

摘要：

痛性糖尿病周围神经病变(DPN)表现为对多数镇痛药物的抵抗。最近许多研究表明,背根神经节(DRG)钠离子通道、丝裂原激活蛋白激酶、一氧化氮、蛋白激酶C、去甲肾上腺素等在DPN疼痛信号转导和痛觉调制方面发挥重要作用。现就DPN疼痛的分子机制及治疗前景作一探讨。

引用

页码：162 / 165

共 9 条

[1] 糖尿病痛性神经病变的诊断和处理 [J].

李洁 ;

李秀钧 .

国外医学内分泌学分册., 2004, (02) :90-92

[2]

Antinociceptive action of a p38α MAPK inhibitor, SD-282, in a diabetic neuropathy model[J] . Sarah M. Sweitzer,Satyanarayana Medicherla,Ramona Almirez,Sundeep Dugar,Sarvajit Chakravarty,Jennifer A. Shumilla,David C. Yeomans,Andrew A. Protter.Pain . 2004 (3)

[3] Amelioration of retarded neurite outgrowth of dorsal root ganglion neurons by overexpression of PKCδ in diabetic rats [J].

Sakaue, Y ;

Sanada, M ;

Sasaki, T ;

Kashiwagi, A ;

Yasuda, H .

NEUROREPORT, 2003, 14 (03) :431-436

[4]

Spinal Nitric Oxide Contributes to the Analgesic Effect of Intrathecal[D-Pen2,D-Pen5]-Enkephalin in Normal and Diabetic Rats[J] . Shao-Rui Chen,Hui-Lin Pan.Anesthesiology . 2003 (1)

[5]

α1-adrenoceptors involvement in painful diabetic neuropathy: a role in allodynia[J] . Young-Ho Lee,Taeg-Geun Ryu,Sang-Joon Park,Eun-Jin Yang,Byeong-Hwa Jeon,Gang-Min Hur,Kwang-Jin Kim.NeuroReport . 2000 (7)

[6] Mitogen-activated protein kinases as glucose transducers for diabetic complications [J].

Tomlinson, DR .

DIABETOLOGIA, 1999, 42 (11) :1271-1281

[7] Tetrodotoxin-resistant sodium channels of dorsal root ganglion neurons are readily activated in diabetic rats [J].

Hirade, M ;

Yasuda, H ;

Omatsu-Kanbe, M ;

Kikkawa, R ;

Kitasato, H .

NEUROSCIENCE, 1999, 90 (03) :933-939

[8] Hyperalgesia and decreased neuronal nitric oxide synthase in diabetic rats [J].

Sasaki, T ;

Yasuda, H ;

Maeda, K ;

Kikkawa, R .

NEUROREPORT, 1998, 9 (02) :243-247

[9]

Early painful diabeticneuropathy is associated with differential changes in tetrodotoxin-sensitiveand -resistant sodium channels in dorsal root ganglion neurons in the rat .2 Hong S,Morrow TJ,Paulson PE,Isom LL. JBiol Chem . 2004

← 1 →