抗PD-1/PD-L1单抗在肿瘤免疫治疗中的应用

被引:15
作者
邱学佳
刘勇
庞国勋
董占军
机构
[1] 河北省人民医院药学部
关键词
PD-1; PD-1/PD-L1抑制剂; 肿瘤免疫治疗; nivolumab;
D O I
暂无
中图分类号
R730.51 [免疫疗法];
学科分类号
100108 [医学免疫学];
摘要
程序性死亡受体-1(programmed death receptor-1,PD-1)/程序性死亡配体-1(programmed death ligand-1,PD-L1)信号通路是介导肿瘤免疫逃逸的主要机制之一,PD-1/PD-L1的单克隆抗体已经在肿瘤的治疗中取得显著的效果。本文对抗PD-1/PD-L1治疗的机制、在临床中的应用及研究进展、抗PD-1/PD-L1治疗与其他治疗的联合治疗等进行综述。探讨PD-1/PD-L1抑制剂在肿瘤治疗中的应用。
引用
收藏
页码:2537 / 2541
页数:5
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[1]
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[2]
Anti-PD-1/PD-L1 therapy of human cancer: past; present; and future[J] Chen; Lieping;Han; Xue Journal of Clinical Investigation 2015,
[3]
Programmed cell death-1 inhibition in lymphoma[J] Eliza A Hawkes;Andrew Grigg;Geoff Chong The Lancet Oncology 2015,
[4]
Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised; controlled; open-label; phase 3 trial[J] Jeffrey S Weber;Sandra P D'Angelo;David Minor;F Stephen Hodi;Ralf Gutzmer;Bart Neyns;Christoph Hoeller;Nikhil I Khushalani;Wilson H Miller;Christopher D Lao;Gerald P Linette;Luc Thomas;Paul Lorigan;Kenneth F Grossmann;Jessica C Hassel;Michele Maio;Mario Sznol;Paolo A Ascierto;Peter Mohr;Bartosz Chmielowski;Alan Bryce;I
[5]
Activity and safety of nivolumab; an anti-PD-1 immune checkpoint inhibitor; for patients with advanced; refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2; single-arm trial[J] Naiyer A Rizvi;Julien Mazières;David Planchard;Thomas E Stinchcombe;Grace K Dy;Scott J Antonia;Leora Horn;Hervé Lena;Elisa Minenza;Bertrand Mennecier;Gregory A Otterson;Luis T Campos;David R Gandara;Benjamin P Levy;Suresh G Nair;Gérard Zalcman;Jürgen Wolf;Pierre-Jean Souquet;Editta Baldini;Federico C
[6]
The PD-1/PD-Ls pathway and autoimmune diseases[J] Suya Dai;Ru Jia;Xiao Zhang;Qiwen Fang;Lijuan Huang Cellular Immunology 2014,