Familial aggregation in inflammatory bowel disease:Is it genes or environment?

被引：9

作者：

Tiago Nunes ^{[1
]}

Gionata Fiorino ^{[2
]}

Silvio Danese ^{[2
]}

Miquel Sans ^{[1
]}

机构：

[1] Department of Gastroenterology Hospital Clinic i Provincial/IDIBAPS CIBER EHD, 08036 Barcelona, Spain

[2] Division of Gastroenterology IRCCS Istituto Clinico Humanitas, Rozzano Milan 20089, Italy

来源：

World Journal of Gastroenterology | 2011年 / 17卷 / 22期

关键词：

Inflammatory bowel disease; Familial aggregation; Familial clustering; Environmental factors; Genetics; Genome wide association studies;

D O I：

暂无

中图分类号：

R574 [肠疾病];

学科分类号：

1002 ; 100201 ;

摘要：

Inflammatory bowel disease (IBD) develops in genetically susceptible individuals due to the influence of environmental factors, leading to an abnormal recognition of microbiota antigens by the innate immune system which triggers an exaggerated immune response and subsequent bowel tissue damage. IBD has been more frequently found in families, an observation that could be due to either genetic, environmental or both types of factors present in these families. In addition to expanding our knowledge on IBD pathogenesis, defining the specific contribution to familial IBD of each one of these factors might have also clinical usefulness. We review the available evidence on familial IBD pathogenesis.

引用

页码：2715 / 2722

页数：8

共 44 条

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