骨骼细胞因子与糖尿病性骨质疏松的关系

被引：8

作者：

牛秀洁

姜崴

机构：

[1] 哈尔滨医科大学附属第一医院内分泌一科

来源：

中华临床医师杂志(电子版) | 2013年 / 7卷 / 03期

关键词：

D O I：

暂无

中图分类号：

R580 []; R587.1 [糖尿病];

学科分类号：

100201 [内科学];

摘要：

<正>骨质疏松症(osteoporosis,OP)是一种常见的代谢性骨病,其特征为骨量减少和骨组织微结构破坏,骨骼脆性增加和骨折风险增大。糖尿病是一种糖、脂代谢异常综合征,长期慢性高血糖致骨形成和骨微环境发生整体性的改变,易合并骨代谢异常及骨质疏松。根据文献报道糖尿病性骨质疏松发病率为38.3%～71%,其发病机制可能与胰岛素的缺乏或作用不足引起体内物质代谢障碍,大量蛋白质和氨基酸被消耗,骨组织内糖蛋白和Ⅰ

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页码：1232 / 1234

页数：3

相关论文

共 15 条

[1]

糖尿病大鼠骨代谢特点的研究观察 [D].

张丽萍 .

山东大学,

2008

[2]

Association between Serum Osteocalcin and Markers of Metabolic Phenotype [J].

Pittas, Anastassios G. ;

Harris, Susan S. ;

Eliades, Myrto ;

Stark, Paul ;

Dawson-Hughes, Bess .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2009, 94 (03) :827-832

[3]

Bone mineral density and its relationship with body mass index in postmenopausal women with type 2 diabetes mellitus in mainland China [J].

Shan, Peng-Fei ;

Wu, Xian-Ping ;

Zhang, Hong ;

Cao, Xing-Zhi ;

Gu, Wei ;

Deng, Xiao-Ge ;

Gu, Chi ;

Liao, Er-Yuan .

JOURNAL OF BONE AND MINERAL METABOLISM, 2009, 27 (02) :190-197

[4]

Is obesity bad for older persons? A systematic review of the pros and cons of weight reduction in later life [J].

Bales, Connie W. ;

Buhr, Gwendolen .

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 2008, 9 (05) :302-312

[5]

Reciprocal regulation of bone and energy metabolism [J].

Lee, Na Kyung ;

Karsenty, Gerard .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2008, 19 (05) :161-166

[6]

Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels [J].

Sugden, J. A. ;

Davies, J. I. ;

Witham, M. D. ;

Morris, A. D. ;

Struthers, A. D. .

DIABETIC MEDICINE, 2008, 25 (03) :320-325

[7]

Endocrine regulation of energy metabolism by the skeleton [J].

Lee, Na Kyung ;

Sowa, Hideaki ;

Hinoi, Eiichi ;

Ferron, Mathieu ;

Ahn, Jong Deok ;

Confavreux, Cyrille ;

Dacquin, Romain ;

Mee, Patrick J. ;

Mckee, Marc D. ;

Jung, Dae Young ;

Zhang, Zhiyou ;

Kim, Jason K. ;

Mauvais-Jarvis, Franck ;

Ducy, Patricia ;

Karsenty, Gerard .

CELL, 2007, 130 (03) :456-469

[8]

Plasma concentrations of osteoprotegerin during normoand hyperglycaemic clamping [J].

Knudsen, S. T. ;

Jeppesen, P. ;

Poulsen, P. L. ;

Andersen, N. H. ;

Bek, T. ;

Schmitz, O. ;

Mogensen, C. E. ;

Rasmussen, L. M. .

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 2007, 67 (02) :135-142

[9]

The mechanism of osteoclast differentiation from macrophages: possible roles of T lymphocytes in osteoclastogenesis [J].

Udagawa, N .

JOURNAL OF BONE AND MINERAL METABOLISM, 2003, 21 (06) :337-343

[10]

Involvement of interleukin-6 and prostaglandin E2 in periarticular osteoporosis of postmenopausal women with rheumatoid arthritis [J].

Sugiyama, T .

JOURNAL OF BONE AND MINERAL METABOLISM, 2001, 19 (02) :89-96