纳美芬的药理作用及临床应用概况

被引:38
作者
任爱国
机构
[1] 军事医学科学院北京
关键词
纳美芬; 芬太尼; 静注; 拮抗作用; 呼吸抑制; 解热镇痛药; 药物作用; 阿片受体拮抗剂; 药理作用; 应用概况;
D O I
暂无
中图分类号
R96 [药理学];
学科分类号
100602 ; 100706 ;
摘要
纳美芬是继纳屈酮之后合成的又一纯阿片受体拮抗剂。其6位亚甲基的化学结构,使它表现出作用时间长、用药途径多、生物利用度高、副作用少的特点。对维持呼吸、循环、消化、内分泌以及神经系统的正常功能均有不同程度的效果。目前已应用于麻醉性镇痛剂呼吸抑制的桔抗、心力衰竭和休克的治疗、酒精中毒和成瘾的治疗以及减肥等。
引用
收藏
页码:66 / 68
页数:3
相关论文
共 9 条
[1]  
Sharer R B, Morley J E.Effects of opioid blockade with nalmefene in older impotent men. Billington C J. Life Sciences . 1990
[2]  
A comparison of YM-14673, U-50488H, and nalmefene after spinal cord injury in the rat. Behrmann D L,Bresnahan J C,Beattie M S. Experimental Neurology . 1993
[3]  
Lower pleasantness of palatable foods in nalmefene-treated human volunteers. Yeomans M R,Wright P. Appetite . 1991
[4]  
Evaluation of the sites of opioid influence on anterior pituitary hormone secretion using a quaternary opiate antagonist. Simpkins J W,Swage D,Millard W J. Neuroendocrinology . 1991
[5]  
Antagonism of fentanyl-induced respiratory depression with nalmefene. Moore L R et al. Methods and Findings in Experimental and Clinical Pharmacology . 1990
[6]  
Changes in transaminases over the course of a 12-week, double-blind nalmefene trial in a 38-year-old female subject. Salvato F R,Mason B J. Alcoholism Clinical and Experimental Research . 1994
[7]  
Human pharmacology and abuse potential of nalmefene. Fudala P J et al. Clinical Pharmacology and Therapeutics . 1991
[8]  
Pharmacology[C]. 2002年中日毒理学和药理学联合研讨会,2002
[9]  
A double-blind, placebo-controlled pilot study to evaluate the efficacy and safety of oral namefene HCl for alcohol dependence. Mason B J et al. Alcoholism Clinical and Experimental Research . 1994