血府逐瘀汤对股骨颈骨折患者TGF-β、VEGF及BMP-2表达的影响

被引:19
作者
熊为
丁金玉
张劲松
周小锐
徐圣康
机构
[1] 十堰市太和医院(湖北医药学院附属医院)骨科
关键词
血府逐瘀汤; 股骨颈骨折; 转化生长因子β; 血管内皮生长因子; 骨形成蛋白-2;
D O I
10.13241/j.cnki.pmb.2016.05.025
中图分类号
R285.6 [中药临床药理];
学科分类号
100806 [中药药理学];
摘要
目的:探讨血府逐瘀汤对股骨颈骨折术后患者转化生长因子β(TGF-β)、血管内皮生长因子(VEGF)、骨形成蛋白-2(BMP-2)表达的影响。方法:选择2014年2月至2014年8月于我院接受治疗的股骨颈骨折患者80例,随机分为实验组和对照组。对照组行常规治疗方案,实验组在常规治疗基础上加用血府逐瘀汤。观察并比较两组患者治疗前后自觉疼痛程度及骨折处骨组织TGF-β、VEGF及BMP-2表达的变化。结果:治疗后,两组患者harris评分均高于治疗前,实验组显著高于对照组(P<0.05)。两组患者的骨折处骨组织TGF-β、VEGF、BMP-2水平均高于治疗前,实验组高于对照组,差异均有统计学意义(P<0.05)。结论:血府逐瘀汤能有效提高股骨颈骨折患者骨折处骨组织TGF-β、VEGF、BMP-2的表达,促进股骨颈骨折的恢复,值得临床应用和推广。
引用
收藏
页码:901 / 903
页数:3
相关论文
共 13 条
[1]
Is There a Difference in Timing and Cause of Death After Fractures in the Elderly? [J].
Liem, Inge S. ;
Kammerlander, Christian ;
Raas, Christoph ;
Gosch, Markus ;
Blauth, Michael .
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2013, 471 (09) :2846-2851
[2]
Total Hip Arthroplasty for the Sequelae of Legg-Calvé-Perthes Disease.[J].Yaser M. K. Baghdadi;A. Noelle Larson;Anthony A. Stans;Tad M. Mabry.Clinical Orthopaedics and Related Research?.2013, 9
[3]
Treatment and Displacement Affect the Reoperation Rate for Femoral Neck Fracture [J].
Murphy, Donavan K. ;
Randell, Timmothy ;
Brennan, Kindyle L. ;
Probe, Robert A. ;
Brennan, Michael L. .
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2013, 471 (08) :2691-2702
[4]
Closed Bone Graft Epiphysiodesis for Avascular Necrosis of the Capital Femoral Epiphysis [J].
Thompson, George H. ;
Lea, Ethan S. ;
Chin, Kenneth ;
Liu, Raymond W. ;
Son-Hing, Jochen P. ;
Gilmore, Allison .
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2013, 471 (07) :2199-2205
[5]
Adherence to a femoral neck fracture treatment guideline [J].
Zielinski, Stephanie M. ;
Meeuwis, Max A. ;
Heetveld, Martin J. ;
Verhofstad, Michiel H. J. ;
Roukema, Gert R. ;
Patka, Peter ;
Van Lieshout, Esther M. M. .
INTERNATIONAL ORTHOPAEDICS, 2013, 37 (07) :1327-1334
[6]
What are the Factors Influencing Outcome Among Patients Admitted to a Hospital With a Proximal Humeral Fracture? [J].
Neuhaus, Valentin ;
Swellengrebel, Christiaan H. J. ;
Bossen, Jeroen K. J. ;
Ring, David .
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2013, 471 (05) :1698-1706
[7]
Use of patient-specific templates in hip resurfacing arthroplasty: experience from sixteen cases [J].
Du, Hao ;
Tian, Xiao-xiao ;
Li, Tong-sen ;
Yang, Jin-sheng ;
Li, Ke-han ;
Pei, Guo-xian ;
Xie, Le .
INTERNATIONAL ORTHOPAEDICS, 2013, 37 (05) :777-782
[8]
Which Implant Is Best After Failed Treatment for Pathologic Femur Fractures? [J].
Forsberg, Jonathan Agner ;
Wedin, Rikard ;
Bauer, Henrik .
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2013, 471 (03) :735-740
[9]
Childhood femoral fracture can lead to premature knee-joint arthritis [J].
Palmu, Sauli A. ;
Lohman, Martina ;
Paukku, Reijo T. ;
Peltonen, Jari I. ;
Nietosvaara, Yrjana .
ACTA ORTHOPAEDICA, 2013, 84 (01) :71-75
[10]
Risk factors for osteoporosis are common in young and middle-aged patients with femoral neck fractures regardless of trauma mechanism [J].
Al-Ani, Amer N. ;
Neander, Gustaf ;
Samuelsson, Bodil ;
Blomfeldt, Richard ;
Ekstrom, Wilhelmina ;
Hedstrom, Margareta .
ACTA ORTHOPAEDICA, 2013, 84 (01) :54-59