酸性微环境在肿瘤中作用的研究进展

被引：14

作者：

杨建芬

机构：

[1] 赣南医学院

来源：

赣南医学院学报 | 2019年 / 39卷 / 04期

关键词：

肿瘤; 肿瘤微环境; 肿瘤发生与发展;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 [肿瘤学];

摘要：

酸性微环境是实体肿瘤的主要特征之一,有氧糖酵解增强、磷酸戊糖途径增强以及缺氧是造成肿瘤酸性微环境的主要原因。近年来研究发现,肿瘤酸性微环境能够促进肿瘤细胞的增殖、侵袭、迁移等细胞恶性生物学行为,还使肿瘤细胞对某些化疗药物产生耐药性以及逃避宿主免疫监视。此外,肿瘤的酸性微环境也为肿瘤的治疗提供了新的方向。本文就酸性微环境的成因、调节机制及其在肿瘤发生发展过程中的作用等进行综述,并阐述针对肿瘤酸性微环境的治疗策略。

引用

页码：396 / 401

页数：6

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