Toll样受体在过敏性疾病、感染性疾病及肿瘤中的研究进展

被引：4

作者：

朱江 ^{[1
,2
]}

肖佳 ^{[3
]}

何世平 ^{[2
]}

姜文奇 ^{[1
,2
]}

郑多 ^{[2
]}

机构：

[1] 中山大学肿瘤防治中心

[2] 深圳大学医学部

[3] 暨南大学生命科学技术学院

来源：

医学研究杂志 | 2015年 / 44卷 / 10期

关键词：

Toll样受体; 过敏性疾病; 感染性疾病; 肿瘤;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100103 [病原生物学];

摘要：

先天性免疫是机体抵御病原体入侵和维持自体稳态的一个重要防御机制。Toll样受体作为先天性免疫机制中的重要受体分子,被认为在多个免疫反应相关的信号通路中起关键作用。Toll样受体家族成员能识别病原信号分子,激活机体免疫系统。然而,在不同疾病中,Toll样受体的激活或抑制将发挥截然不同的作用。本文重点阐述了Toll样受体在过敏性疾病、感染性疾病和肿瘤中的研究进展,并讨论了Toll样受体及相关药物在这些疾病中的应用。

引用

收藏

页码：5 / 7+11 +11

页数：4

相关论文

共 14 条

[1]

Maintenance treatment with the immunomodulator MGN1703, a Toll-like receptor 9 (TLR9) agonist, in patients with metastatic colorectal carcinoma and disease control after chemotherapy: a randomised, double-blind, placebo-controlled trial [J].

Schmoll, Hans-Joachim ;

Wittig, Burghardt ;

Arnold, Dirk ;

Riera-Knorrenschild, Jorge ;

Nitsche, Dieter ;

Kroening, Hendrik ;

Mayer, Frank ;

Andel, Johannes ;

Ziebermayr, Reinhard ;

Scheithauer, Werner .

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2014, 140 (09) :1615-1624

[2]

TLR2 Signaling Decreases Transmission of Streptococcus pneumoniae by Limiting Bacterial Shedding in an Infant Mouse Influenza A Co-infection Model [J].

Richard, Aimee L. ;

Siegel, Steven J. ;

Erikson, Jan ;

Weiser, Jeffrey N. .

PLOS PATHOGENS, 2014, 10 (08)

[3]

High-mobility group box 1 (HMGB1) protein regulates tumor-associated cell migration through the interaction with BTB domain. [J].

Ko, Young Bok ;

Kim, Boh-Ram ;

Nam, Sang Lyun ;

Yang, Jung Bo ;

Park, Sang-Yoon ;

Rho, Seung Bae .

CELLULAR SIGNALLING, 2014, 26 (04) :777-783

[4]

IFNγ expression by an attenuated strain of Salmonella enterica serovar Typhimurium improves vaccine efficacy in susceptible TLR4-defective C3H/HeJ mice [J].

Al-Ojali, Samia M. ;

Moore, C. B. Tara ;

Fernandez-Cabezudo, Maria J. ;

al-Ramadi, Basel K. .

MEDICAL MICROBIOLOGY AND IMMUNOLOGY, 2013, 202 (01) :49-61

[5]

Phase I clinical trial of CpG oligonucleotide 7909 (PF-03512676) in patients with previously treated chronic lymphocytic leukemia [J].

Zent, Clive S. ;

Smith, Brian J. ;

Ballas, Zuhair K. ;

Wooldridge, James E. ;

Link, Brian K. ;

Call, Timothy G. ;

Shanafelt, Tait D. ;

Bowen, Deborah A. ;

Kay, Neil E. ;

Witzig, Thomas E. ;

Weiner, George J. .

LEUKEMIA & LYMPHOMA, 2012, 53 (02) :211-217

[6]

The macrophage response towards LPS and its control through the p38 MAPK –STAT3 axis.[J]..Cellular Signalling.2012, 6

[7]

Toll-like receptor-7 ligand imiquimod induces type I interferon and antimicrobial peptides to ameliorate dextran sodium sulfate-induced acute colitis [J].

Sainathan, Satheesh K. ;

Bishnupuri, Kumar S. ;

Aden, Konrad ;

Luo, Qizhi ;

Houchen, Courtney W. ;

Anant, Shrikant ;

Dieckgraefe, Brian K. .

INFLAMMATORY BOWEL DISEASES, 2012, 18 (05) :955-967

[8]

Study of the Expression of Toll-Like Receptors in Different Histological Types of Colorectal Polyps and Their Relationship with Colorectal Cancer [J].

Eiro, Noemi ;

Gonzalez, Lucia ;

Gonzalez, Luis O. ;

Andicoechea, Alejandro ;

Fernandez-Diaz, Maria ;

Altadill, Antonio ;

Vizoso, Francisco J. .

JOURNAL OF CLINICAL IMMUNOLOGY, 2012, 32 (04) :848-854

[9]

DAMPening Inflammation by Modulating TLR Signalling.[J].A. M. Piccinini;K. S. Midwood;Andrew Parker.Mediators of Inflammation.2010,

[10]

Toll-like receptors: Expression and involvement in Multiple Myeloma.[J].David Chiron;Gaetan Jego;Catherine Pellat-Deuceunynck.Leukemia Research.2010,