miRNA在肾脏疾病的应用研究进展

被引：6

作者：

陈丹 ^{[1
]}

刘光陵 ^{[2
]}

机构：

[1] 南京中医药大学

[2] 解放军第三九医院

来源：

中国医师杂志 | 2014年 / 16卷 / 06期

关键词：

微RNAs; 肾疾病; 足细胞; 肾小管;

D O I：

暂无

中图分类号：

R692 [肾疾病];

学科分类号：

100221 [泌尿外科学];

摘要：

<正>肾小球的滤过功能、肾小管的重吸收和分泌功能是肾脏代谢产物,调节水、电解质和酸碱平衡、维持机内环境稳定的基础。当肾小球、肾小管受损引起肾脏功能失调,导致肾脏疾病的发生,肾脏病的早诊断、早治疗有助于阻止疾病的恶化,改善疾病预后与转归。miRNA参与细胞增殖、分化、凋亡等生物过程,与机体免疫应答、基因调节等密切相关[1]。人类将近1/3基因编码的mRNA都受其调控。笔者就miRNA在肾脏疾病的应用研究进展作一综述。

引用

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