癫痫大鼠海马结构谷氨酸和nNOS神经元的动态变化

被引：14

作者：

姚君茹

潘三强

吕来清

宿宝贵

高秀来

机构：

[1] 首都医科大学解剖学教研室

[2] 暨南大学医学院解剖学教研室

[3] 首都医科大学解剖学教研室北京

[4] 北京

来源：

解剖学杂志 | 2004年 / 05期

关键词：

癫痫; 化学点燃; 海马结构; 谷氨酸; 一氧化氮合酶; 大鼠;

D O I：

暂无

中图分类号：

R742.1 [癫痫];

学科分类号：

1002 ;

摘要：

目的 :探讨谷氨酸 (Glu)和一氧化氮 (NO)二者在癫痫模型中的作用及其相关性。方法 :戊四唑化学点燃癫痫大鼠 ,分为Ⅰ、Ⅲ、Ⅴ级组和Ⅴ级后 2 4h组。采用免疫组织化学方法和图像分析技术。结果 :( 1 )Ⅲ、Ⅴ级组Glu免疫反应阳性神经元数目和平均光密度值升高 ;但Ⅴ级比Ⅲ级组有所下降 ;Ⅴ级后 2 4h组恢复到对照组水平。 ( 2 )Ⅴ级组和Ⅴ级后 2 4h组nNOS免疫反应阳性神经元数目和平均光密度值升高。结论 :戊四唑点燃癫痫模型中 ,随着点燃级别的进展 ,Glu的含量是呈先增加后减少的趋势 ,而NO的含量是逐渐增加的 ,提示二者在癫痫发作中既有相关性又有独立性

引用

页码：505 / 508+488 +488

页数：5

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