水分子对磺酰脲类分子构效关系影响的研究

被引：3

作者：

马翼

刘洁

李正名

机构：

[1] 南开大学元素有机化学国家重点实验室!元素有机化学研究所

[2] 天津

来源：

高等学校化学学报 | 2000年 / 01期

关键词：

溶剂作用; 水; 磺酰脲; ALS酶; 结构与活性关系;

D O I：

暂无

中图分类号：

O641 [结构化学];

学科分类号：

摘要：

A study of some sulfonylurea molecules with consideration of water molecules as its solvent was undertaken. The influence of the water molecules on the structure-activity relationship of the 35 sulfonylurea molecules was discussed . By supper-imposition of structural sulfonyl molecules, a molecular RMS was correlated with pI50, which denotes that the configuration difference in water solution is one of the reasons which causes the difference in bioactivity.

引用

页码：85 / 87

页数：3

共 4 条

[1] 应用CoMFA研究磺酰脲类化合物的三维构效关系 [J].