对乙酰氨基酚肝肾毒性及其解毒药物的研究进展

被引：47

作者：

杜雨蒙

丁劲松

机构：

[1] 中南大学药学院

来源：

中南药学 | 2013年 / 11卷 / 02期

关键词：

对乙酰氨基酚; 肝毒性; 肾毒性; 解毒药物;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100706 [药理学];

摘要：

<正>对乙酰氨基酚(paracetamol,APAP)是乙酰苯胺类解热镇痛药,它是非那西丁的主要代谢产物,在20世纪50年代开始得到普遍应用。因其常用剂量安全可靠,在多数国家为非处方药,是国际医药市场上头号解热镇痛药。目前,对

引用

页码：112 / 116

页数：5

共 12 条

[1]

对乙酰氨基酚肝毒性机理及药物干预靶点 [J].

汪倩 ;

徐瑞娟 ;

杨劲 .

药学与临床研究, 2011, 19 (03) :247-252

[2]

S-腺苷蛋氨酸在健康及受损肝脏中的作用及新机制探讨 [J].

高志良 .

临床消化病杂志, 2008, 20 (06) :377-380

[3]

急性对乙酰氨基酚中毒的急诊处理原则 [J].

李瑾 ;

赵剡 ;

许喜咏 .

内科急危重症杂志, 2007, (02) :106-107

[4]

Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat [J].

Yousef, Mokhtar I. ;

Omar, Sahar A. M. ;

El-Guendi, Marwa I. ;

Abdelmegid, Laila A. .

FOOD AND CHEMICAL TOXICOLOGY, 2010, 48 (11) :3246-3261

[5]

A case of acetaminophen (paracetamol) causing renal failure without liver damage in a child and review of literature [J].

Ozkaya, Ozan ;

Genc, Gurkan ;

Bek, Kenan ;

Sullu, Yurdanur .

RENAL FAILURE, 2010, 32 (09) :1125-1127

[6]

Curcumin prevents oxidative renal damage induced by acetaminophen in rats [J].

Cekmen, M. ;

Ilbey, Y. O. ;

Ozbek, E. ;

Simsek, A. ;

Somay, A. ;

Ersoz, C. .

FOOD AND CHEMICAL TOXICOLOGY, 2009, 47 (07) :1480-1484

[7]

Cytoprotective effect of arjunolic acid in response to sodium fluoride mediated oxidative stress and cell death via necrotic pathway [J].

Ghosh, Jyotirmoy ;

Das, Joydeep ;

Manna, Prasenjit ;

Sil, Parames C. .

TOXICOLOGY IN VITRO, 2008, 22 (08) :1918-1926

[8]

UK legislation on analgesic packs: before and after study of long term effect on poisonings [J].

Hawton, K ;

Simkin, S ;

Deeks, J ;

Cooper, J ;

Johnston, A ;

Waters, K ;

Arundel, M ;

Bernal, W ;

Gunson, B ;

Hudson, M ;

Suri, D ;

Simpson, K .

BMJ-BRITISH MEDICAL JOURNAL, 2004, 329 (7474) :1076-1079

[9]

Nephrotoxicity after acute severe acetaminophen poisoning in adolescents [J].

Boutis, K ;

Shannon, M .

JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY, 2001, 39 (05) :441-445

[10]

Paracetamol hepatotoxicity and microsomal function [J].

Kaushal, R ;

Dave, KR ;

Katyare, SS .

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 1999, 7 (01) :67-74

← 1 2 →