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Progesterone is neuroprotective against ischemic brain injury through its effects on the phosphoinositide 3-kinase/protein kinase B signaling pathway[J] . T. Ishrat,I. Sayeed,F. Atif,F. Hua,D.G. Stein.Neuroscience . 2012
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Immunoreactive Akt, PI3-K and ERK protein kinase expression in ischemic rat brain[J] . Hisashi Kitagawa,Hitoshi Warita,Chihoko Sasaki,Wen Ri Zhang,Kenichi Sakai,Yoshihoko Shiro,Yasuhide Mitsumoto,Toyoki Mori,Koji Abe.Neuroscience Letters . 1999 (1)
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Neuroprotective effect of hu-manin on cerebral ischemia/reperfusion injury is mediated bya PI3 K/Akt pathway .2 Xu X,Chua CC,Gao J,et al. Brain Res . 2008
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Proline-rich Akt substrate of40kDa (PRAS40): a novel downstream target ofPI3k/Akt signaling pathway .2 Wang H,Zhang Q,Wen Q,Zheng Y,Philip L,Jiang H,Lin J,Zheng W. Cell Signal . 2012