对神经氨酸酶处理去涎的血浆进行高压琼脂糖电泳后,分别应用免疫固定和溶血覆盖技术调查了我国武汉地区汉族180人的C4多态现象。在C4A座位发现5个变型:C4A4、3、2、1和91;在C4B座位发现6个变型:C4B 3、2、1、92、9W和96。两个座位均有静息等位基因(C4A*QO和C4B*QO)存在。它们相应的基因频率为:C4A*4,0.014;3,0.633;2,0.192;1,0.011;91,0.003;QO,0.147;C4B*3,0.006;2,0.127;1,0.751;92,0.041;9W,0.003;96,0.006;QO,0.0660单零C4A(c4A QO)表型个体占总体28.3%,单零C4B(C4B QO)占11.1%;纯合C4A缺乏(C4A QO,QO)和纯合C4B缺乏(C4BQO,QO)分别占0.56%。和1.11%卡方测验表明,C4A和C4B基因频率分别符合Hardy-Weinberg遗传平衡定律。