脑梗死患者血清TNF-α、IL-1β含量的变化及其临床意义的研究

被引：46

作者：

陈明生

朱瑞芬

詹庆盈

机构：

[1] 福建省龙岩市第一医院神经内科!龙岩

[2] 山东医科大学附属第一医院!济南

来源：

中国神经免疫学和神经病学杂志 | 2001年 / 01期

关键词：

脑梗死; 肿瘤坏死因子; 白介素1;

D O I：

暂无

中图分类号：

R743.33 [脑栓塞];

学科分类号：

1002 ;

摘要：

目的　了解脑梗死患者血清TNF α、IL 1β含量在恢复期和急性期的变化及意义。方法　运用双抗夹心酶联免疫吸附法 (ELISA)测定血清中TNF α、IL 1β的含量。结果　急性期、恢复期脑梗死患者血清TNF α、IL 1β水平较对照组显著增高 (P <0 .0 1) ,急性期又较恢复期高 (P <0 .0 5 ,P <0 .0 1) ;增高程度与神经功能缺损程度及梗死体积大小密切相关。结论　TNF α、IL 1β可能参与脑梗死早期的炎症反应及再灌注损伤 ,并在其中起重要作用。

引用

页码：32 / 34

页数：3

共 8 条

[1]

Lavine SD,Holan FM,Zlokovic BV.Circulation antiboby agaist tumor necrosis factor-alpha protects rat brain from reperfusion injuy. Journal of Cerebral Blood Flow and Metabolism . 1998

[2]

Buttini M,APPel K,Sauter A,et al.Expression of tumor necrosis factor alpha after focal cerebral ischemia in the rat. Neuroscience . 1996

[3]

Mccanon RM,Doron DA,Siren AL,et al.Agoniststimulated release of von Willebrand factor and procoagulant risk factor for stroke. Brain Research . 1994

[4]

Kao TY,Chio CL,Liu MT.Hypothalamic dopamine release and local cerebral blood flow during onset of heatstroke in rat. Stroke . 1994

[5]

Anna LS,Eliahu H,David D,et al.Release of proinflammatory and prothrombotic mediators in the brain and peripheral circulation in spontaneously hypertensive and normotensive wistar-kyoto rats. Stroke . 1992

[6]

Neurology[C]. The 5th International Congress of Pathophysiology,2006

[7]

Betz AL,Schielke GP,Yang GY.Interleukin-1 in cerebral ischemia. Keio Journal of Medicine . 1996

[8]

Feuerstein GZ,Liu T,Barone FC.Cytokines, inflammation and brain injury: role of tumor necrosis factor-α. Cerebrovascular and Brain Metabolism Reviews . 1994

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