双酚A的表观遗传作用机制研究进展

被引：3

作者：

王冲

徐立

机构：

[1] 陕西中医药大学医学科研实验中心

来源：

环境与健康杂志 | 2018年 / 35卷 / 08期

关键词：

双酚A; 表观遗传; DNA甲基化; 组蛋白修饰;

D O I：

10.16241/j.cnki.1001-5914.2018.08.022

中图分类号：

R114 [卫生毒理];

学科分类号：

100235 [预防医学];

摘要：

目的双酚A(bisphenol A,BPA)是人们日常生活中广泛接触的一种环境内分泌干扰物(environmental endocrine disruptors,EEDs),其普遍使用给人们的健康造成了潜在的风险。长期暴露于BPA中可对动物产生(如改变发情周期和大脑性别二态性、损害认知等)不良影响,且这些不利的影响能延续到后代。BPA引起的对动物长期不良影响的分子机制研究发现其涉及到表观遗传修饰。该文回顾了表观遗传修饰的概念和分类,综述了BPA对表观遗传修饰特别是DNA甲基化影响的最新研究进展,为进一步揭示BPA暴露影响健康的机制提供了新思路。

引用

页码：744 / 747

页数：4

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