疏血通对大鼠脑出血后脑水肿的影响

被引：15

作者：

宋林

姜亚平

钟高贤

机构：

[1] 武汉市同济医院神经内科

来源：

卒中与神经疾病 | 2004年 / 06期

关键词：

脑出血; 脑水肿; 疏血通;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

摘要：

目的　探讨应用疏血通对大鼠脑出血后脑水肿的影响以及用药的安全性。方法　将胶原酶用定向注入法注入大鼠一侧的尾壳核制作大鼠脑出血模型 ,并在注入胶原酶后 4h通过大鼠尾静脉注入疏血通 ,通过观察大鼠的脑组织含水量、K+ 、Na+ 的含量以及血肿体积来评价疏血通的影响。结果　疏血通治疗组的大鼠脑组织含水量较对照组明显低 (P <0 .0 1) ,两组间脑组织K+ 、Na+ 的含量有明显差异 (P <0 .0 5 ) ,而血肿体积无明显差异。结论　疏血通能减轻大鼠脑出血后脑水肿 ,并且不引起血肿增大。其可能是治疗脑出血后脑水肿的一种安全有效的药物。

引用

页码：342 / 344

页数：3

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