Ⅳ型胶原酶的研究进展

被引:5
作者
肖大凯
机构
[1] 广东医学院医用生化研究所广东湛江
关键词
Ⅳ型胶原酶; 肿瘤; 血管生成; 侵袭; 转移; 信号传导;
D O I
暂无
中图分类号
R730.2 [肿瘤病理学、病因学];
学科分类号
100214 ;
摘要
Ⅳ型胶原酶是一类在肿瘤的生长、向远端侵袭和转移过程发挥重要作用的基质金属蛋白酶 ,本文就Ⅳ型胶原酶的结构 ,活性调节及其与信号传导 ,肿瘤侵袭和转移 ,血管生成的关系的研究进展加以综述
引用
收藏
页码:225 / 226+231 +231
页数:3
相关论文
共 13 条
[1]  
Gum R,Lengyel E,Jurez J,et al.Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequence. Journal of Biological Chemistry . 1996
[2]  
Aplin AE,Juliano RL.Intergrin and cytoskeletal regulation of growth factor signaling to the MAP kinase pathway. Journal of Cell Science . 1999
[3]  
Finchan VJ,James M,Frames MC,et al.Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesion by integrin engagement and v-src. EMBO Journal . 2000
[4]  
Bottle KD,Bullen EC,Updike DL,et al.Gelatinase A expression in endothelial cells is regulated by at least two cis-acting promoter elements. Biochemistry and Biophysics . 1999
[5]  
Barrantes SH,Toth M,Bernardo MM,et al.Binding of active ( 57 kDa) membrane type 1-matrix metalloproteinase( MT1-MMP ) to tissue inhibitor of metalloproteinase(TIMP)-2 regulates MT1-MMP processing and pro-MMP-2 activation. Journal of Biological Chemistry . 2000
[6]  
McCawley LJ,Li SN,Wattenberg EV,et al.Sustained activation of the mitogen-activated protein kinase pathway. Journal of Biological Chemistry . 1999
[7]  
Still K,Robson CN,Autzen P,et al.Localization and quantification of mRNA for matrix metalloproteinase-2 (MMP-2)and tissue inhibitor of matrix metalloproteinase (TIMP-2) in human benign and malignant prostatic tissue. Prostate . 2000
[8]  
Pozzi A,Moberg PE,Miles LA,et al.Elevated matrix metalloproteinase and angiostatin levels in integrin α1 knockout mice cause reduced tumor vascularization. Proceedings of the National Academy of Sciences of the United States of America . 2000
[9]  
Fang J,Shing Y,Wiederschain D,et al.Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model. Proceedings of the National Academy of Sciences of the United States of America . 2000
[10]  
O’Reilly MS,Wiederschain D,Stetler-Stevenson WG,et al.Regulation of angiostatin production by matrix metalloproteinase-2 in a model of concomitant resistance. Journal of Biological Chemistry . 1999